GMP Manufacturer Factory Price API 99% Cefprozil hydrate Cas 121123-17-9

Superiority:

English name: Cefprozil hydrate

CAS number: 121123-17-9

Molecular formula: C18H21N3O6S

Molecular weight: 407.44

Melting point:>194°C(dec.)

Storage condition:Keep in dark place

Cephalosporins are a class of broad-spectrum semi-synthetic antibiotics whose parent nucleus is the parent nucleus containing 7-aminocephalosporanic acid (7-ACA) obtained by cleavage of cephalosporin C. Different groups are added to the 7-position carbon atom to form various cephalosporins with different antibacterial activities and pharmacokinetic properties. This kind of drug has the advantages of strong antibacterial effect, resistance to penicillinase, high clinical efficacy, low toxicity, and less allergic reaction than penicillin. The mechanism of action of cephalosporins is the same as that of penicillins, mainly by interfering with the synthesis of peptidoglycan, the main component of bacterial cell wall. Cephalosporins are divided into four generations according to their antibacterial spectrum, stability to β-lactamase and antibacterial activity against G-bacteria. The activity of the second-generation cephalosporins against gram-positive cocci is similar to or slightly worse than that of the first-generation cephalosporins, but has enhanced effects on gram-negative bacilli such as Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. β-lactamase-producing Haemophilus influenzae, Moraxella catarrhalis, Neisseria meningitidis, and Neisseria gonorrhoeae are also active. The stability of β-lactamase produced by gram-negative bacilli is stronger than that of the first-generation cephalosporins; it has mild or no nephrotoxicity; commonly used varieties are cefaclor, cefuroxime, cefprozil and cefoti install. Cefprozil, also known as Cefprozil, Cefprox, Kekezhi, Yin Lishu, Cefzir, Shifujie, is a second-generation oral cephalosporin antibiotic, which is effective against Gram-positive cocci such as Staphylococcus, Streptococcus pneumoniae, Streptococcus Cocci have good antibacterial activity, high antibacterial effect against Haemophilus influenzae and Moraxella catarrhalis; ineffective against methicillin-resistant Staphylococcus and Enterococcus faecalis, poor antibacterial activity against other gram-negative bacilli; against anaerobic bacteria Most of the bacteria have a certain inhibitory effect, and have no antibacterial effect on most of the fragilis. Stabilized against plasmid-mediated beta-lactamases. In terms of antibacterial activity, cefprozil is slightly higher than cefalexin and cefradine, and similar to cefaclor and cefuroxime. The effect on Enterococcus is better than other cephalosporins, slightly inferior to amoxicillin; the effect on Gram-positive cocci and influenza bacilli is similar to that of cefaclor and cefuroxime; the effect on Enterobacteriaceae is better than cephalosporin Ampicillin, similar to cefaclor and cefuroxime. This product is stable to plasmid-mediated β-lactamase. It is suitable for the treatment of mild to moderate upper respiratory tract infections (otitis media, pharyngitis, tonsillitis, sinusitis, etc.), lower respiratory tract infections (bronchitis and pneumonia), skin and soft tissue infections, and simple urinary tract infections caused by sensitive bacteria.

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