Hot Sale High Purity 99% Pharmaceutical Chemicals Aminophylline Powder CAS No. 317-34-0

Superiority:

English name: Aminophylline

CAS Number: 317-34-0

Molecular formula: C9H16N6O2

Molecular weight: 240.27

EINECS Number: 206-264-5

1. Relax airway smooth muscle: Aminophylline can relax airway smooth muscle and relieve bronchospasm.

2. Immunomodulatory and anti-inflammatory effects: A small amount of aminophylline can inhibit the release of inflammatory mediators from mast cells and relieve airway smooth muscle spasm; it can also inhibit bronchial eosinophil infiltration.

3. Enhance respiratory muscle contractility: Prevent diaphragmatic fatigue and respiratory failure by improving respiratory function.

4. Excite the breathing center: Excite breathing and enhance the depth of breathing, but the breathing frequency does not increase.

5. Strengthen the heart: Act on the heart, antagonize adenosine, prevent excessive release of adenosine, expand coronary arteries and peripheral blood vessels, promote myocardial contraction, and increase cardiac output.

6. Diuresis: increase renal blood flow and glomerular filtration rate, and inhibit the reabsorption of renal tubules.

It is suitable for bronchial asthma, wheezing bronchitis, sleep apnea syndrome and premature infant asphyxia, chronic obstructive pulmonary disease COPD, and relieve wheezing symptoms. It can also be used for acute cardiac insufficiency and cardiogenic asthma.

1. Treatment of pulmonary hypertension: Aminophylline can directly change the concentration of Ca2+ in the pulmonary artery wall and reduce the outflow of Ca2+, inhibit PDE to relax smooth muscle, reduce pulmonary vascular resistance and pulmonary artery pressure, reduce pulmonary vascular extravasation, and eliminate pulmonary edema.

2. Treatment of sleep apnea syndrome and premature infant asphyxia: Aminophylline stimulates the respiratory center, promotes the release of catecholamine sympathetic neurotransmitters, enhances diaphragmatic muscle contraction and hypoxia response, and is effective for sleep apnea, and children are better than adults. For premature infants, asphyxia can also excite the myocardium and prevent bradycardia.

3. Prevention and treatment of drowsiness and respiratory depression after general anesthesia: Aminophylline excites the center, lowers the threshold of carbon dioxide-induced breathing initiation, increases the body's responsiveness to pain, nerve-muscle conduction function and muscle tone, and reverses respiratory depression.

4. Treatment of refractory cough: It is suitable for cough caused by cold or inhalation of irritating gas, but it is necessary to exclude organic lesions of lung and bronchus.

5. Treatment of arrhythmia: During myocardial ischemia, the release of adenosine increases significantly, which can cause angina pectoris, bradycardia, atrioventricular block and so on. After intravenous infusion of adenosine triphosphate, the atrioventricular block caused by different degrees can be eliminated by low-dose aminophylline. The occurrence of sick sinus syndrome may also be related to changes in the number of adenosine receptors, increased sensitivity, or abnormally slow breakdown of adenosine.

6. Treatment of acute nephritis and hemorrhagic fever with renal syndrome: aminophylline can inhibit the formation of thrombus and anti-basement membrane antibodies, dilate renal blood vessels, increase renal blood flow and filtration rate, improve renal microcirculation, and activate glomerular urinary tract function and contribute to the relief of renal failure.

7. Treatment of aplastic anemia: Aminophylline can stimulate hematopoietic stem cells, expand blood vessels in the bone marrow, and is conducive to the production of granulocytes.

8. Treatment of transplant rejection: Aminophylline is an immunomodulatory drug that selectively activates suppressor T cells. Inhibit acute rejection in patients with hormone tolerance, reduce serum creatinine and increase urine output.