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Avibactam Sodium Best Price Avibactam Sodium NXL 104
Product name: avibactam sodium
CAS No:1192491-61-4
Appearance: white powder
Molecular weight: 287.226
Molecular formula:C7H10N3NaO6S
Items | Standards | Results |
Appearance | White or off-white solid powder | Complies |
Identification | By IR | Complies |
By HPLC | Complies | |
Reaction of sodium salt | Complies | |
Solubility | Freely soluble in Water; very sparingly soluble in Ethanol | Complies |
Polymorphism | Form 1 | Complies |
pH | 7.0~9.0 | 7.90 |
Loss on Drying | ≤ 1.00% | 0.08% |
Heavy Metals | ≤ 20ppm | Complies |
Residue on Ignition | ≤ 0.10% | 0.05% |
Residual Solvents | Ethanol: ≤5000 ppm | 410ppm |
Ethyl acetate:≤5000 ppm | ND | |
Isopropanol:≤5000 ppm | ND | |
Related Substance | Any Single Unknown Impurity: ≤ 0.10% | 0.09% |
Total Impurities: ≤ 0.50% | 0.21% | |
Enantisomer | ≤ 0.15% | ND |
Purity(by HPLC) | ≥99.0% | 99.79% |
Bulk density | ≤ 1.00 | Complies |
Tapped density | ≤ 1.00 | Complies |
Particle Size | D90 ≤180μm | Complies |
Bacterial Endotoxin Limit | ≤ 1.1 IU/mg | Complies |
Reference Standard | In-house Standard | |
Conclusion | The product complied to In-house standard. | |
Storage | Preserve in tight,light-resistant containers in a cool place |
Avibactam (avibactam, NXL-104) belongs to the diazabicyclooctanone compound and is currently the most promising non-beta-lactam inhibitor. It has no obvious antibacterial activity, but can inhibit type A ( Including ESBL and KPC) and C-type β-lactamases. Therefore, when used in combination with various cephalosporins and carbapenem antibiotics, it has broad-spectrum antibacterial activity, especially against Escherichia coli and Klebsiella pneumoniae containing extended-spectrum β-lactamase, and those containing excess AmpC enzyme. E. coli and E. coli containing both AmpC and extended-spectrum β-lactamase showed significant activity.
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