99% Purity High Quality API Ambrisentan CAS 177036-94-1

Superiority:

Chronic obstructive pulmonary disease (COPD) is a common clinical serious respiratory disease, with an incidence of more than 50%. Pulmonary hypertension (PH) is one of the complications of COPD. Its causes are related to pulmonary vasoconstriction and pulmonary vascular remodeling caused by chronic hypoxia. Severe PH can lead to increased right ventricular pressure, right ventricular hypertrophy, myocardial congestion and edema, and intermittent Right ventricular remodeling and right heart failure occur. Lowering pulmonary artery pressure is very important for patients with COPD. It can not only improve the ventilation-to-blood flow ratio, but also reduce the load on the right heart, which is beneficial to slow down the lungs. The occurrence of heart disease. According to the "2010 Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension", the diagnostic criteria for pulmonary hypertension is the mean pulmonary arterial pressure (mPAP) of 25 mmHg detected by right heart catheterization at sea level and at rest. Normal mPAP is (14 ± 3) mmHg, with a maximum of 20 mmHg. According to the results of the Chinese Idiopathic and Familial PAH Registry, the most common symptoms were shortness of breath and fatigue after exercise (98.6%), chest pain (29.2%), syncope (26.4%), hemoptysis (20.8%), and palpitations (9.7%). %), other symptoms include lower extremity edema, chest tightness, dry cough, angina pectoris, abdominal distension and hoarseness. At present, there are not many types of drugs for reducing pulmonary artery pressure. Ambrisentan is a selective endothelin receptor antagonist, which can reduce endogenous vasoconstriction, anti-proliferation and anti-inflammatory effects.

Treatment of pulmonary arterial hypertension with WHO grade II or III symptoms to improve exercise capacity and delay clinical deterioration.

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1. quality
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1. We has 11 years' exporting experience in pharmaceutical ingredient products.

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