Pharmaceutical Chemical Factory Supply Esomeprazole Sodium CAS 161796-78-7

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Esomeprazole sodium is the sodium salt form of esomeprazole. It is a commonly used anti-ulcer drug. It was first successfully developed by AstraZeneca in Sweden. It is a proton pump inhibitor. The drug of choice for acid-related diseases such as ulcers and gastroesophageal reflux disease. At present, there are five PPIs commonly used in clinical practice: omeprazole, lansoprazole, rabeprazole, pantoprazole and esomeprazole. Omeprazole, as the first PPI drug, has been unanimously recognized for its efficacy in the treatment of acid-related diseases. Esomeprazole is the S-isomer of omeprazole, which reduces gastric acid secretion through a specific targeting mechanism and is a specific inhibitor of proton pumps in parietal cells. Due to its metabolic advantages, esomeprazole Compared with omeprazole, sodium azole has higher bioavailability and more consistent pharmacokinetics, which increases the amount of drugs reaching the proton pump, and is significantly better than lansoprazole, pantoprazole and radon in controlling gastric acid. Other proton pump inhibitors such as beprazole. In animal experiments, this product has a dose-dependent inhibitory effect on the activity of Na+/K+ ATPase on isolated rabbit gastric parietal cells, and its IC50 is 60μmol/L. The efficacy is greater than that of omeprazole (IC50 is 100μmol/L). At the same time, esomeprazole sodium can also inhibit the accumulation of 14C aminopyrine in isolated human gastric parietal cells caused by histamine, and the effect is twice as strong as omeprazole. Intravenous or enteral injection of esomeprazole sodium into the experimental ostomy rat model can inhibit the secretion of gastric acid caused by histamine, and its ED50 is 0.24 and 0.43 mg/kg, respectively. The ED50 of omeprazole administered by the same route were 0.30 and 0.68 mg/kg, respectively. Intestinal use of esomeprazole sodium in pylorus ligated rats can reduce the basal gastric acid secretion, and the effect is 3 times stronger than that of omeprazole. The drug can also prevent stress-induced or alcohol-induced gastric injury in experimental rats and has preventive and therapeutic effects on gastric injury caused by indomethacin and acetic acid, and its ED50 values ??are 1.6 and 5.5 mg/kg, respectively. It can be seen from the above experimental results that the efficacy of esomeprazole on ulcers is greater than that of omeprazole. In addition, there are experimental data showing that when esomeprazole sodium is combined with penicillin and clarithromycin, it can effectively treat duodenal ulcers and peptic ulcers caused by Helicobacter pylori infection

English name: Esomeprazole sodium

CAS number: 161796-78-7

Molecular formula: C34H36MgN6O6S2

Molecular weight: 713.12

EINECS Number: 620-470-6

Melt point: 156°C(approx)

Storage conditions: Inert atmosphere, Storeinfreezer, under-20°C

1. Treatment of acid-related diseases such as peptic ulcer and gastroesophageal reflux disease

2. Treats hypersecretion of gastric acid

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