High Quality GMP manufacturer Pharmaceutical Cytarabine CAS 147-94-4

Superiority:

1.Cytarabine is a purine nucleoside antiviral drug first extracted from Streptomyces culture solution and then chemically synthesized. It is a white crystalline powder, very slightly soluble in water, and its monophosphate is easily soluble in water. . It has inhibitory effect on DNA viruses such as herpes simplex virus HSV1 and HSV2, hepatitis B virus, varicella-zoster virus and cytomegalovirus, but has no effect on smallpox virus, adenovirus, other DNA or RNA viruses, bacteria and fungi . The exact antiviral mechanism of cytarabine has not been fully elucidated, and it is mainly related to the inhibition of virus replication. Drugs and their metabolites block the synthesis of viral DNA by inhibiting the DNA polymerase of the virus, while the drug itself only penetrates into the DNA molecule of the virus in a very small amount. The drug is not immunosuppressive. Intravenous administration of 75% to 87% of the drugs in the body is rapidly deaminated by adenosine deoxygenase into arabinose hypoxanthine, the antiviral activity is significantly lower than the original, and it is quickly distributed in some tissues; 10 mg per kilogram of body weight is administered , the peak blood concentration of arabinose hypoxanthine is 3～6μ/ml, the peak blood concentration of arabinosine is 0.2～0.4μg/ml, arabinose hypoxanthine can pass through the blood-brain barrier, and the concentration of cerebrospinal fluid is about 1/3 of the plasma drug concentration. 41% to 53% of the daily dose is excreted from the urine in the form of arabinose hypoxanthine, and 1% to 3% is excreted as the prototype drug. Clinically, cytarabine is mainly used to treat herpes simplex encephalitis, and also used to treat herpes zoster and chickenpox infection in immunosuppressed patients, but it is ineffective against cytomegalovirus. It also has the pharmacological activity of inhibiting the replication of hepatitis B virus. Topical for herpes simplex keratitis and occasionally for vaccinia keratitis.

2.Cytarabine, also known as Yamashan cytarabine, cytarabine hydrochloride, cytosine arabinoside, cytosine arabinoside, cytosine arabinoside, Sedsa, Sedway, is currently clinically used in my country. One of the most effective drugs for the treatment of acute non-lymphocytic myeloid leukemia. Synthesized for the first time in 1959, it also exists in sponges. In 1961, it was found to have inhibitory effects on mouse sarcoma S180 and leukemia L1210. Cytarabine and commonly used antineoplastic drugs, 6-thioguanine, methotrexate, prednisone, vincristine, nitrogen mustard, cyclophosphamide, daunorubicin, amihydrazone, fluorouracil and mercaptopurine No cross-resistance has been found in animal experiments. This drug is a pyrimidine antimetabolite antitumor drug, which is cell cycle specific and most sensitive to S-phase cells. It interferes with cell proliferation by inhibiting the synthesis of cellular DNA. Cytarabine enters the human body and is converted into cytarabine triphosphate and cytarabine diphosphate by kinase phosphorylation. The former can strongly inhibit the synthesis of DNA polymerase, while the latter can inhibit the conversion of cytarabine diphosphate into cytarabine diphosphate. Deoxycytidine diphosphate inhibits the synthesis and polymerization of cellular DNA. The inhibitory effect on RNA and protein synthesis is very slight.
 

[Indications] Clinically, it is mainly used for the treatment of acute lymphocytic and non-lymphocytic leukemia in the induction phase and maintenance phase, the blast phase of chronic myeloid leukemia and the treatment of malignant lymphoma, ophthalmology for the treatment of viral keratitis and epidemic conjunctivitis. It also has a certain curative effect on head and neck cancer, digestive tract cancer and lung cancer; in addition, this medicine can inhibit the reproduction of herpes simplex virus, smallpox virus, vaccinia virus and the immune response of the body.

Ara-C inserts into DNA and forms a complex with topoisomerase I (topoisomerase I) to inhibit DNA replication, resulting in DNA cleavage. Does not inhibit RNA synthesis. Anti-leukemia substances for various types of acute leukemia.

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