99% Factory Low Price Alogliptin Benzoate CAS 850649-62-6

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Factory Low Price Alogliptin Benzoate CAS 850649-62-6
Alogliptin (trade name Nesina in the US and Vipidia in Europe) is an orally administered anti-diabetic drug in the DPP-4 inhibitor class, developed by Syrrx, a company which was acquired by Takeda Pharmaceutical Company in 2005. Like other medications for the treatment of Type 2 diabetes, alogliptin does not decrease the risk of heart attack and stroke. Like other members of the gliptin class, it causes little or no weight gain, exhibits relatively little risk of causing hypoglycemia, and exhibits relatively modest glucose-lowering activity. Alogliptin and other gliptins are commonly used in combination with metformin in patients whose diabetes cannot adequately be controlled with metformin alone. In April 2016, the U.S. FDA added a warning about increased risk of heart failure.

Alogliptin benzoate (alogliptin), also known as alogliptin, is a serine protease dipeptidyl peptidase IV (DPP-IV) inhibitor developed by Takeda Corporation of Japan. This product can maintain the level of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulin-stimulating polypeptide (GIP) in the body, and promote the secretion of insulin, thereby exerting a hypoglycemic effect. Results of a randomized, placebo-controlled clinical trial showed that alogliptin monotherapy significantly improved glycemic control in patients with type 2 diabetes compared with placebo, did not increase the incidence of hypoglycemia, and was well tolerated. Alogliptin and its pharmaceutical composition are oral and effective specific DPP-IV inhibitors following the introduction of sitagliptin and vildagliptin, which provide a new and important treatment option for patients with type 2 diabetes. application prospects. Alogliptin benzoate was officially launched in my country in early 2014. It is the first type 2 diabetes treatment drug approved in my country with proven cardiovascular safety data, which provides more and better treatment for type 2 diabetes. Good choice.

Incretin is a peptide hormone produced by the gastrointestinal tract after meals, which can promote the secretion of insulin from pancreatic β cells. It includes glucagon-like peptide-1 (GLP-1) and glucose-dependent insulin-stimulating peptide (GIP). Secreted by L cells in the ileum and colon and K cells in the duodenum, respectively. GLP-1 and GIP are active hormones that are released into the blood circulation within minutes after ingestion of food, but are rapidly deactivated by the serine protease DPP-4. Postprandial incretin levels are significantly lower in patients with type 2 diabetes, so preventing incretin inactivation to increase its duration of action will effectively lower blood sugar. As a DPP-4 inhibitor, alogliptin benzoate can reduce the inactivation of GLP-1 in vivo by selectively inhibiting DPP-4, and increase the level of GLP-1 in the body, thereby reducing blood sugar. When blood sugar drops to normal levels, it will not continue to exert its hypoglycemic effect, so it can effectively reduce the risk of hypoglycemia. In addition, DPP-4 inhibitors can delay gastric emptying, increase satiety, suppress appetite, and help patients lose weight. Therefore, while these drugs can effectively lower blood sugar, they can also reduce the risk of hypoglycemia and weight gain, overcome the obstacles of patients reaching the standard of treatment, and bring new hope to the treatment of diabetes.

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