Bulk in Stock Bivalirudin Powder Buy Online with Good Price CAS: 128270-60-0

Superiority:

English name: Bivalirudin

CAS number: 128270-60-0

Molecular formula: C98H138N24O33

Molecular weight: 2180.29

EINECS Number: 274-570-6

Density: 1.52±0.1 g/cm3(Predicted)

Storage conditions: -20°C

Form: powder

Color: white to off-white

Bivalirudin is a new synthetic anticoagulant drug, which is a direct, specific and reversible inhibitor of thrombin. It was initially successfully developed by the Swiss company Biogen, and was later transferred to the Medicines Company of the United States. It was approved for listing in the United States in 2000. Its anticoagulant component is a 20-peptide compound derived from hirudin. Whether it is thrombin in the blood circulation or thrombin bound to the thrombus, bivalirudin can specifically bind to its catalytic site and anion binding site, thereby directly inhibiting the activity of thrombin, and its effect is short-lived ,reversible. Early clinical studies have shown that bivalirudin anticoagulation is effective and has a lower incidence of bleeding events, and it is safer to use than traditional heparin anticoagulation. It is mainly used to prevent ischemic complications before and after angioplasty intervention for unstable angina pectoris. In vitro, this product has inhibitory effect on both soluble and thrombus-bound thrombin, which is not affected by the product released by platelets, and prolongs the activated partial thromboplastin time of normal human plasma in a dose-dependent manner. Enzyme time and prothrombin time. For patients with unstable angina pectoris undergoing percutaneous coronary intervention (PCI). In 2010, the number of PCI operations in China reached 300,000, with a compound annual growth rate of over 30%. It can be seen that the sales prospect of bivalirudin after its listing is considerable. Clinical experiments have shown that in the peri-PCI application, the efficacy of bivalirudin is better than the current mainstream combination of unfractionated heparin/low molecular weight heparin + platelet glycoprotein receptor antagonist, especially the bleeding risk is significantly reduced, which greatly improves the use of anticoagulants. Safety: (1) It can significantly reduce the incidence of bleeding in patients with elective PCI, and the risk of total clinical outcomes is reduced by 14%. (2) Does not cause antibody-mediated thrombocytopenia. (3) Reversible combination with thrombin, short half-life, ischemia and hemorrhagic complications are not easy to occur. (4) The main excretion does not pass through the kidney, so it can be safely used in patients with renal impairment

As an alternative to unfractionated heparin and platelet glycoprotein IIb/IIIa antagonists

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