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Baloxavir Marboxil CAS 1985606-14-1 Baloxavir
English name: Baloxavir marboxil
CAS number: 1985606-14-1
Molecular formula: C27H23F2N3O7S
Molecular weight: 571.55
Boiling point: 712.8±70.0°C (Predicted)
Density: 1.57±0.1g/cm3(Predicted)
Storage conditions: Sealed in dry, Store in freezer, under -20°C
Acidity coefficient: (pKa)-1.46±0.40(Predicted)In February 2018, the new anti-influenza drug Baloxavirmarboxil (trade name: Xofluza), developed by Shionogi of Japan and jointly researched by Roche of Switzerland, received accelerated approval and was approved for marketing in Japan. Baloxavir dipivoxil is an innovative Cap-dependent endonuclease inhibitor and one of the few new drugs in the world that can inhibit the proliferation of influenza virus. In June 2018, the U.S. Food and Drug Administration (FDA) accepted the new drug application for baloxavir dipivoxil and granted it priority review status.
Baloxavir dipivoxil is indicated for patients ≥12 years of age who suffer from acute uncomplicated influenza and whose symptoms do not exceed 48 hours. Attention should be paid to the limitations of drug use: influenza virus changes over time, and there are factors such as virus types and subtypes. Once the drug resistance of the virus and the pathogenicity of the virus change, the clinical efficacy of antiviral drugs may be weakened. Available information on the susceptibility of locally circulating virus strains to the drug should be considered when taking basalovir dipivoxil or not. Baloxavir dipivoxil is a prodrug, which is hydrolyzed into the body into the active substance baloxavir to exert anti-influenza virus activity. Baloxavir is an anti-influenza drug with a novel mechanism of action that inhibits the cap-dependent endonuclease in influenza virus, thereby blocking the transcription of the virus's own mRNA. The half-life of baloxavir is about 80 hours, and only one dose is required.
Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together. Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.
Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.
An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.
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Our professional and thoughtful after-sales service eliminates your worries.
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(1)Any inquiries will be replied within 12 hours.
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Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.
The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions.
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.
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