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Poziotinib (HM781-36B) CAS 1092364-38-9 Lower Price Poziotinib (HM781-36B)
English name: Poziotinib (HM781-36B)
CAS number: 1092364-38-9
Molecular formula: C23H21Cl2FN4O3
Molecular weight: 491.34
Melting point: 187-190°C
Boiling point: 629.7±55.0°C (Predicted)
Density: 1.409±0.06g/cm3(Predicted)
Storage conditions: -20°C Freezer, Under inert atmospherePoziotinib (HM781-36B) is a novel oral cancer cell inhibitor for the treatment of NSCLC, breast cancer and gastric cancer, and has a targeted small molecule inhibitor of tyrosine kinase. It has a strong inhibitory effect on gefitinib and erlotinib-resistant EGFRL858R/T790M double mutant cells. The combination of Poziotinib (HM781-36B) and 5-fluorouracil, platinum compound, paclitaxel or gemcitabine showed a good synergistic inhibitory effect on the overexpression of human epidermis No. 2 (HER2), which is the second generation tyrosine A novel third-generation anti-tumor cell inhibitor after the kinase inhibitor afatinib.
Poziotinib specifically inhibits the growth of HER2-amplified gastric cancer cells and inhibits the phosphorylation of EGFR and key components of the downstream signaling cascades, such as STAT3, AKT and ERK. Poziotinib also induces apoptosis and G1 cell cycle arrest by activating the mitochondrial pathway in HER2-amplified gastric cancer cells. Furthermore, Poziotinib exhibited synergistic effects with chemotherapeutic agents in HER2-induced and HER2-non-amplified gastric cancer cells.
Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together. Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.
Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.
An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.
1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.
2.We can provide you with ten thousands of products of different levels.
3. We offer convenient one-station purchasing service.
(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.
Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.
The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions.
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.
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