Pharmaceutical Grade GMP Manufacturer CAS 9001-54-1 Hyaluronidase

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What is Hyaluronidase:
Hyaluronic acid lyase, also known as hyaluronidase or "Hyaluronidase for Injection", is a kind of enzyme that can hydrolyze hyaluronic acid. Hyaluronic acid lyase is a natural enzyme, which has hydrolysis effect on hyaluronic acid. It eliminates the injections of inappropriate parts and eliminates the excessive injection of hyaluronic acid, resulting in the elimination rate of 90%. It is mainly used to repair the failure of hyaluronic acid shaping. Hyaluronic acid lytic enzyme is a substance that dissolves hyaluronic acid. After hyaluronic acid injection, it doesn't feel very good after cosmetology. It can be dissolved in hyaluronic acid within 48 hours, and then it can be filled with hyaluronic acid again.

Hyaluronidase, which is an enzyme that breaks down hyaluronic acid, has been used in medical applications for over 60 years. ... Its current off-label uses include dissolving hyaluronic acid fillers, treating granulomatous foreign body reactions, and treating skin necrosis associated with filler injections.

Hyaluronidase, an enzyme that breaks down hyaluronic acid, has long been used to increase the absorption of drugs into tissue and to reduce tissue damage in cases of extravasation of a drug. With the increasing popularity of hyaluronic acid filler, hyaluronidase has become an essential drug for the correction of complications and unsatisfactory results after filler injection. For this reason, when performing procedures using hyaluronic acid filler, a sufficient knowledge of hyaluronidase is required. In order for hyaluronidase to dissolve a hyaluronic acid filler, it must interact with its binding sites within the hyaluronic acid. The reaction of a filler to hyaluronidase depends on the hyaluronic acid concentration, the number of crosslinks, and the form of the filler. Hyaluronidase is rapidly degraded and deactivated in the body. Therefore, in order to dissolve a hyaluronic acid filler, a sufficient amount of hyaluronidase must be injected close to the filler. If the filler is placed subcutaneously, injection of hyaluronidase into the filler itself may help, but if the filler is placed within a blood vessel, it is sufficient to inject hyaluronidase in the vicinity of the vessel, instead of into the filler itself.

Hyaluronidase is an enzyme extracted from mammalian testis that can hydrolyze glass mucopolysaccharide. It is a white or slightly yellow powder, easily soluble in water, but insoluble in ethanol, acetone or ether. Odorless. The stability is good, 420C continuous heating for 60min does not lose the vitality, and 1000C continuous heating for 5min can retain 80% of the vitality. It is easy to be deactivated in low concentration aqueous solution, and can generally be protected from deactivation by gelatin or gum arabic. Fe2+, Cu2+ ions can reversibly inhibit the enzyme. Pb2+, Hg2+, Ni2+, plasma had no obvious effect on enzyme activity. Inhibitory effect of chondroitin sulfate B (dermatan), heparin sulfate, keratan sulfate, heparin sodium and high concentration of hyaluronic acid on hyaluronidase in the presence of sodium chloride (0.15mol/L) or protamine sulfate can be reversed. Hyaluronidase injection is a sterile product of hyaluronidase plus appropriate excipients, freeze-dried, and is a white or off-white freeze-dried block or powder. The aqueous solution is unstable and needs to be prepared before use.

Hyaluronidase can act as a cleavage enzyme. It can generally be used to accelerate the absorption of intramuscular and subcutaneous injection liquids, relieve pain at the injection site, promote the infiltration of local anesthetics, and help promote the dissipation of local edema or hematoma after surgery and trauma. Can also be used for intestinal adhesions. However, salicylates can inhibit the action of hyaluronidase. Not for intravenous injection. Do a skin test before use to avoid allergic reactions. Infected and swollen areas are disabled to prevent spread. The LD50 of subcutaneous injection in mice was >250,000 units/kg; the LD50 of intramuscular injection of mice was >12,500 units/kg. Subcutaneous or intramuscular injection, 150~1500U/time, 1~2 times a day, first dissolve with normal saline or water for injection, and then mix with other injections; for subcutaneous infusion, add 150U of this product to 100ml large infusion. This product is an antihypertensive drug.