High Purity Peptide Powder Desmopressin Acetate CAS 16789-98-3

Superiority:

English name: Desmopressin acetate

CAS number: 16789-98-3

Molecular formula: C48H68N14O14S2

Molecular weight: 1129.28

EINECS Number: 634-101-1

Melting point: 170-172°C (dec.)

Storage conditions: −20°C

In recent years, the newly synthesized vasopressin substances, that is, the 1-position cysteine and 8-position L-arginine of fine vasopressin are replaced by β-mercaptopropionic acid and D-arginine, respectively. The vasopressin effect of this product is 2000 times smaller than that of refined vasopressin, and the antidiuretic effect is stronger and more durable than natural vasopressin, with a half-life 3 times longer.

Desmopressin acetate (DDAVP, Micong), which is the deamination of 1-cysteine and the replacement of 8-L-arginine with 8-D-arginine, also known as aminoarginine vasopressin , is a structural analog of natural arginine vasopressin, a derivative of vasopressin, its antidiuretic effect is more powerful and durable than vasopressin, but it has no vasoconstriction effect, and the side effects of the drug are small. Congenital or drug-induced platelet dysfunction, uremia, liver cirrhosis and prolonged bleeding due to unknown reasons; it can be used to control and prevent bleeding during minor surgery; central diabetes insipidus, etc. In individual cases, this product is even effective in patients with moderate urological diseases and is often contraindicated in patients with von Willebrand disease IIB.

1. Shorten or return to normal the prolonged bleeding time before interventional therapy or diagnostic surgery; suitable for patients with congenital or drug-induced platelet dysfunction, uremia, liver cirrhosis and prolonged bleeding time due to unknown etiology. Shorten or normalize prolonged bleeding time.

2. Patients with mild hemophilia A and von Willebrand disease who have a positive reaction to the test dose of this product can be used to control and prevent bleeding during minor surgery. In individual cases, this product may even be effective in patients with moderate disease. Contraindicated in patients with type IIB von Willebrand disease.

3. Central diabetes insipidus. This product can be used for the treatment of central diabetes insipidus. After administration, it can increase urine osmotic pressure and reduce plasma osmotic pressure, thereby reducing urine excretion, urination frequency and nocturia.

4. Renal urine concentration function test. This product can be used to test renal urine concentration function, which is helpful for the diagnosis of renal function; it is especially effective for diagnosing the degree of urinary tract infection; cystitis is different from pyelonephritis, so it does not cause subnormal renal urine Liquid concentration function. Indications: von Willebrand disease, urinary tract infection, diabetes insipidus, urinary tract infection, uremia, liver cirrhosis, cystitis, hemophilia, nephritis, pediatric hemophilia, pediatric diabetes insipidus