Safe Delivery Pharmaceutical intermediates Lower Price CAS 59985-21-6 Diquafosol

Safe Delivery Pharmaceutical intermediates Lower Price CAS 59985-21-6 Diquafosol

Min.Order / FOB Price:Get Latest Price

1 Gram	FOB Price:USD 0.0200 -0.0300

1 Gram

FOB Price:USD 0.0200 -0.0300

Min.Order :1 Gram
Purity: 99%+
Payment Terms : L/C,D/A,D/P,T/T,Other

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Diquafosol Lower Price Diquafosol CAS 59985-21-6

Quick Details

Appearance:White powder
Application:The corneal epithelium is essential for maintaining clear and transparent vision. If corneal epithelium damage occurs, it must be repaired quickly to avoid corneal opacity and vision loss caused by th
PackAge:bag or barrel or drum
ProductionCapacity:6000|Metric Ton|Day
Storage:Store at room temperature
Transportation:by express or air or sea

Superiority:

English name: Diquafosol

CAS number: 59985-21-6

Molecular formula: C18H26N4O23P4

Molecular weight: 790.31

Density: 2.044±0.06 g/cm3(Predicted)

Acidity coefficient: (pKa) 0.40 ± 0.50 (Predicted)

Diquafosol is a dinucleotide derivative that acts on P2Y2 receptors on the membranes of conjunctival epithelial cells and goblet cells, and promotes the secretion of aqueous fluid from conjunctival epithelial cells and the secretion of goblet cell mucin. In a double-blind clinical trial, diquafosol sodium was similar to and better than sodium hyaluronate in the treatment of corneal and conjunctival lesions, respectively. In a 52-week open-label clinical trial, diquafosol sodium was effective and safe. Based on the above results, diquafosol sodium was launched in Japan in December 2010. Diquafosol sodium is a P2Y2 receptor agonist, which acts on the P2Y2 receptors on the conjunctival epithelium and goblet cell membrane, and improves dry eye disease by up-regulating intracellular calcium ion concentration and promoting the secretion of water and mucin. symptom. This product was developed by Santen Pharmaceutical after obtaining authorization from Inspire Pharmaceuticals (a subsidiary of Merck), and was first approved in Japan in October 2010 for the treatment of dry eye.

The corneal epithelium is essential for maintaining clear and transparent vision. If corneal epithelium damage occurs, it must be repaired quickly to avoid corneal opacity and vision loss caused by the invasion of pathogens and endothelial damage. Extracellular nucleotides such as ATP and UTP have been reported to play a role in epithelial wound healing by activating P2Y receptors (P2YRs) mediated including intracellular calcium transport as well as EGF receptors (EGFR) and ERK of phosphorylation, thereby promoting the corneal epithelial wound-healing response. Diquafosol sodium is a UTP dimer derivative and an agonist of the P2Y2 receptor (P2Y2R). On the ocular surface, P2Y2R is expressed in the cornea, conjunctival goblet cells and meibomian glands. In the conjunctival epithelium, diquafosol sodium can accelerate the efflux of water through the activation of chloride channels after increasing intracellular calcium ions. In addition, diquafosol sodium promotes mucin secretion in conjunctival goblet cells and improves tear film stability on the ocular surface.

Details:

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together. Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.

1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions.
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.

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