Desloratadine Powder 99% CAS 100643-71-8 Pharmaceutical Chemical

Desloratadine Powder 99% CAS 100643-71-8 Pharmaceutical Chemical

Min.Order / FOB Price:Get Latest Price

1 Gram	FOB Price:USD 0.0200 -0.0300

1 Gram

FOB Price:USD 0.0200 -0.0300

Min.Order :1 Gram
Purity: 99%+
Payment Terms : L/C,D/A,D/P,T/T,Other

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Quick Details

Appearance:White powder
Application:Including chronic idiopathic urticaria, perennial allergic rhinitis and other allergic diseases. In addition, it can relieve the symptoms of cold urticaria. 1. Treatment of allergic rhinitis (AR) with
PackAge:bag or barrel or drum
ProductionCapacity:6000|Metric Ton|Day
Storage:Store at room temperature
Transportation:by express or air or sea

Superiority:

Product Name	Desloratadine
CAS NO.	100643-71-8
Appearance	White powder
Purity	99%
Melting Point	150-151 °C(lit.)
Boiling point	467.9±45.0 °C(Predicted)
Application	Pharmaceutical raw materials; chemical intermediates; raw materials and intermediates; API
Chemical structure
Usage	Respiratory system and anti-allergic medication
Storage	Normal Temperature

1. Strong anti-allergic effect desloratadine specifically binds to H1 receptors with high selectivity. Among the currently known antihistamines, it has the strongest binding ability to H1 receptors and has significant anti-H1 receptors. body effect. It is 4 times more potent than loratadine in inhibiting histamine-induced mouse foot swelling. Desloratadine inhibits the release of inflammatory cytokines, including IL-3, IL-6, TNF-α, GM-CSF, etc., from stimulated human mast cells and basophils at nanomolar levels. The inhibitory effect is stronger than that of dexamethasone and cetirizine.

2. Quick onset and long-lasting effect Desloratadine itself has activity, good absorption, and the onset time is less than 30min. The maximum plasma concentration was reached about 3h after oral administration, the Cmax was 3.98ng·mL-1 when a single dose was administered, and the clearance rate was 114-201L·h-1. A clinical study on the onset time of allergic rhinitis patients showed that desloratadine has a faster onset of action than existing antihistamines, with an average onset time of 28.45min, while loratadine and mizolastine for 1h, cetirizine for 2h. The half-life is about 24h, and the effect is long-lasting.

Including chronic idiopathic urticaria, perennial allergic rhinitis and other allergic diseases. In addition, it can relieve the symptoms of cold urticaria. 1. Treatment of allergic rhinitis (AR) with specific mediators such as histamine, prostaglandin D2, leukotrienes C4, IL-3, IL-8, ICAM-1, etc. that play a unique role in early and late allergic reactions Increased awareness has led to the emergence of many therapeutic routes targeting the allergic cascade. Desloratadine can effectively inhibit the release of inflammatory mediators at multiple sites in this cascade, thereby preventing various symptoms of AR (such as nasal congestion, etc.). 2. The clinical trial for the treatment of chronic idiopathic urticaria (CIU) showed that desloratadine could reduce the frequency of itching in CIU patients by 75% within 6 hours. The clinical trial of desloratadine on CIU led by the First Affiliated Hospital of Nanjing Medical University and the Department of Dermatology of Huashan Hospital affiliated to Fudan University in China showed that after the first dose of desloratadine was applied for 2 and 4 weeks, the largest wheal was observed. The size, number of wheals, pruritus and total symptom scores, the patient's score can be improved by up to 80%, indicating that desloratadine has a good effect on CIU. The overview, action characteristics, clinical application, and safety of desloratadine are organized by Dongfang editors.

Details:

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together. Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.

1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions.
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.

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