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English name: Rupatadine Fumarate

CAS number: 182349-12-8

Molecular formula: C26H26ClN3.C4H4O4

Molecular weight: 532.03

EINECS Number: 1592732-453-0

Melting point: 196-198°C

Storage Conditions: Sealed in dry, 2-8°C

Solubility:Methanol (Slightly, Heated)

Form:Solid

Color: White to Pale Brown

Rupatadine Fumarate (FR, RupatadineFumarate) chemical name is 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridine)methyl]-4-piperidine yl]-5H-benzocycloheptano[1,2-b]pyridine fumarate. It was successfully developed by the Spanish pharmaceutical company Uriach and was first marketed in Spain in 2003. It is a new generation of tricyclic antihistamines with dual effects of antihistamine and antagonism of platelet activating factor (PAF). It is also the only powerful and highly effective anti-allergic drug that has both antihistamine effect and PAF antagonistic activity currently on the market.

Rupatadine fumarate is a selective histamine H1 receptor inverse agonist and PAF antagonist. In animal experiments in mice, rats, guinea pigs, rabbits and dogs, the drug showed strong antihistamine effects and PAF receptor blocking effects. The ileal function test of guinea pigs was used to compare the activity of rupatadine and other antihistamines, and the results showed that rupatadine was more active than terfenadine, loratadine, cetirizine, hydroxyzine, Diphenhydramine is stronger and comparable to desloratadine. In a single-dose expansion trial in healthy people, 10 mg of rupatadine inhibited PAF-induced erythema with a mean maximal inhibition of 41% and 20 mg of 56%. In addition, this product has inhibitory effects on mast cell degranulation, neutrophil and eosinophil migration, and cytokine release.

Rupatadine fumarate can selectively block H1 receptors, but has only weak blocking effect on serotonin, acetylcholine, prostaglandin F2, and leukotriene D4, and can still non-compete with platelet activating factor receptors Sexual binding inhibits degranulation of sensitized cells with the advantages of no cardiovascular toxicity and potential proarrhythmic effects, and no central sedative effects. Because of its clear mechanism of action, good bioavailability, stable curative effect and good safety treatment window, it has attracted many people in the medical field to carry out improved research on its synthesis method.

Q1.Are you a manufacturer or a trading company
A1.Our company is a leading manufacturer specializing in trade and the development, production and marketing of pharmaceutical intermediates and apis for more than 10 years.
Q2.What about the quality of your products
A2.We value quality as life.We strictly control the quality of each process, established a perfect quality control system.
Q3.In the third quarter.What is your minimum order quantity
A3.Our minimum order quantity is 1 gram.
Q4.Fourth quarter.Can you provide free test samples
A4.Yes, we can provide 10g free samples for consumer test.
Q5.What is your delivery time
A5.Delivery takes 2-3 days, depending on the destination.
Q6.What about the mode of transportation
A6.For urgent and light orders, UPS, FedEx, DHL, EMS can be used;For heavier goods, we provide the method of air or sea transportation to consumers.
Q7.So far.How about the terms of payment
A7.We accept T/T,  Paypal, , money gram, etc.