ERYTHROMYCIN OXIME Quality Erythromycin a 9- Oxime Raw Powders CAS No 13127-18-9

ERYTHROMYCIN OXIME Quality Erythromycin a 9- Oxime Raw Powders CAS No 13127-18-9

Min.Order / FOB Price:Get Latest Price

1 Gram	FOB Price:USD 0.0200 -0.0300

1 Gram

FOB Price:USD 0.0200 -0.0300

Min.Order :1 Gram
Purity: 99%+
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

CAS 13127-18-9 ERYTHROMYCIN OXIME Erythromycin a 9- Oxime

Quick Details

Appearance:White powder
Application:antibiotics
PackAge:bag or barrel or drum
ProductionCapacity:6000|Metric Ton|Day
Storage:Store at room temperature
Transportation:by express or air or sea

Superiority:

Product Name	Erythromycin A Oxime
CAS number	13127-18-9
Molecular formula	C37H68N2O13
Molecular weight	748.94
Appearance	white to slightly yellow powder
Flash Point	462.4ºC
Boiling point	841ºC at 760 mmHg
Relative density	1.28g/cm3

Erythromycinoxime, white or off-white crystalline powder, is an important intermediate for the synthesis of second and third generation macrolide antibiotics such as roxithromycin, azithromycin, clarithromycin and dirithromycin. For example, the process of synthesizing azithromycin is as follows: (1) Synthesis of erythromycin oxime: react erythromycin thiocyanate with hydroxylamine at 30-60°C for 10-36 hours, and then neutralize it with alkali to obtain erythromycin oxime; (2) ) Synthesis of erythromycin A-6,9-imine ether: dissolve the erythromycin oxime obtained in step (1) in an acetone-water system, so that the mass ratio of acetone to water is 0.5～0.8:2～2.5, add Methanesulfonyl chloride and sodium hydroxide, react at pH 9.7-10.5 and 3-5°C for 3-4 hours, and centrifuge; (3) Synthesis of 9-deoxy-9a-aza-9a-isoerythromycin: the The product obtained in step (2) is added to water, adjusted to pH 5.5 to 6.5 at 0 to 5°C, potassium borohydride is added after complete dissolution, dichloromethane is added after the reaction is completed for 2 to 4 hours, and the pH is adjusted to 9.5 to 10.0 and then separated. , retain the organic layer, add the organic layer to water and hydrolyze at pH 1.0 to 1.5, adjust the pH of the water to 9.5 to 10 after liquid separation, and reduce the temperature to 30 to 35 ° C for crystallization; (4) Synthesis of azithromycin: the steps (3) gained crystallization, acetone are warming up to 33～37 ℃, add formaldehyde, formic acid temperature rising and reflux reaction 2～3 hours, control temperature drips water at 18～22 ℃, dripping speed is 250～300L/hour, reaction solution becomes muddy and stops Add dropwise, continue to add water dropwise after stirring at a rate of 350 to 450L/hour, add water to crystallize and centrifuge to obtain wet azithromycin product; (5) Refining: crystallize the wet product of azithromycin in an acetone-water system, throw Filter and dry.

Q1.Are you a manufacturer or a trading company
A1.Our company is a leading manufacturer specializing in trade and the development, production and marketing of pharmaceutical intermediates and apis for more than 10 years.
Q2.What about the quality of your products
A2.We value quality as life.We strictly control the quality of each process, established a perfect quality control system.
Q3.In the third quarter.What is your minimum order quantity
A3.Our minimum order quantity is 1 gram.
Q4.Fourth quarter.Can you provide free test samples
A4.Yes, we can provide 10g free samples for consumer test.
Q5.What is your delivery time
A5.Delivery takes 2-3 days, depending on the destination.
Q6.What about the mode of transportation
A6.For urgent and light orders, UPS, FedEx, DHL, EMS can be used;For heavier goods, we provide the method of air or sea transportation to consumers.
Q7.So far.How about the terms of payment
A7.We accept T/T, Paypal, , money gram, etc.

Details:

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together. Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.

1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions.
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.

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