GMP Manufacturer Supply High Purity API Powder CAS 161735-79-1 Rasagiline Mesylate

Superiority:

English name: Rasagiline mesylate

CAS number: 161735-79-1

Molecular formula: C13H17NO3S

Molecular weight: 267.34398

EINECS Number: 694-423-3

Melting point: 155-158°C

Storage bar: 2-8°C

Solubility: H2O: ≥20mg/mL

Morphology powder color :white to tan

Rasagiline mesylate was developed by Teva Pharmaceutical Industries in Israel and was first approved by the European Medicines Agency (EMA) on February 21, 2005 and approved by the U.S. Food and Drug Administration on May 16, 2006 (FDA) approved for marketing. It is suitable for monotherapy (without levodopa) in patients with primary Parkinson's disease, and as an adjunct to levodopa for Parkinson's patients with end-dose fluctuations. Rasagiline mesylate is an irreversible monoamine oxidase inhibitor. By selectively inhibiting monoamine oxidase, it can reduce the decomposition of dopamine and increase the extracellular level of dopamine in the high striatum of the brain. The increased dopamine level can alleviate the symptoms of Parkinson's disease. Rasagiline mesylate is 5 to 10 times stronger than selegiline (the first-generation monoamine oxidase inhibitor, including stigmaline, midopyridine, and Jinsiping), which is 5 to 10 times stronger for long-term use of dopa preparations. Patients with declining efficacy also improved. In addition, the metabolite of rasagiline is an inactive non-amphetamine substance with few side effects. What's more, rasagiline mesylate is also neuroprotective, unlike other antiparkinsonian drugs. Combined therapy can optimize the therapeutic effect of levodopa, further effectively control symptoms and reduce motor complications. According to IMS data in the United States in 2017, among the top 500 best-selling drugs in the world, the anti-Parkinsonian treatment market was US$2.056 billion, a year-on-year increase of 3.73%.

The pharmacological mechanism of rasagiline: Rasagiline is a potent, highly selective, irreversible monoamine oxidase-B inhibitor, which can inhibit the degradation of dopamine, increase the accumulation of dopamine, promote the release of dopamine, and improve the clinical symptoms of PD patients. It has a novel chemical structure designed to ameliorate the deficiencies of first-generation MAO-B inhibitor therapy. Selegiline is a first-generation MAO-B inhibitor, and its metabolites include amphetamine derivatives, which can cause adverse reactions, such as affecting patient sleep. The metabolites of rasagiline do not contain amphetamine derivatives. In vitro studies have confirmed that aminoindane, a metabolite of rasagiline, has neuroprotective effects. The binding of rasagiline to MAO-B is highly selective, which is characterized by maintaining a distance of two carbon units between the aromatic ring and the N-propargyl terminal in the structure, and an additional effective group N-propargylamine group The triple bond is essential for maintaining the irreversible effects of rasagiline. The irreversible effect means that the effect is continuous, so it may provide continuous dopaminergic stimulation (continuous dopaminergicstimulation, CDS). This is the basis for achieving once-daily dosing; data show that the pharmacokinetic half-life of rasagiline is independent of the pharmacodynamic half-life, and clinical efficacy can last up to 24 hours.

Q1.Are you a manufacturer or a trading company
A1.Our company is a leading manufacturer specializing in trade and the development, production and marketing of pharmaceutical intermediates and apis for more than 10 years.
Q2.What about the quality of your products
A2.We value quality as life.We strictly control the quality of each process, established a perfect quality control system.
Q3.In the third quarter.What is your minimum order quantity
A3.Our minimum order quantity is 1 gram.
Q4.Fourth quarter.Can you provide free test samples
A4.Yes, we can provide 10g free samples for consumer test.
Q5.What is your delivery time
A5.Delivery takes 2-3 days, depending on the destination.
Q6.What about the mode of transportation
A6.For urgent and light orders, UPS, FedEx, DHL, EMS can be used;For heavier goods, we provide the method of air or sea transportation to consumers.
Q7.So far.How about the terms of payment
A7.We accept T/T,  Paypal, , money gram, etc.