Clotrimazole CAS 23593-75-1 Raw Material Pharmaceutical Chemicals

Superiority:

English name: Clotrimazole

CAS number: 23593-75-1

Molecular formula: C22H17ClN2

Molecular weight: 344.84

EINECS Number: 245-764-8

Melting point: 147-149°C

Boiling point: 501.14°C (rough estimate)

Density: 1.1095 (rough estimate)

Refractive index: 1.5940 (estimate)

Storage conditions: 2-8°C

Solubility:Soluble in chloroform,DMSO,DMF and alcohols

Form: neat

Acidity coefficient: (pKa)pKa4.7(EtOH50%aq)(Uncertain)

Water solubility: <10mg/L(25ºC)

Maximum wavelength: (λmax) 556nm (Phosphatebuffersol.) (lit.)

Merck: 14,2417

Clotrimazole is a synthetic pyrrole antifungal drug, which has inhibitory effect on a variety of pathogenic fungi, and can also have bactericidal effect at high concentrations. Clotrimazole inhibits the biosynthesis of fungal ergosterol and other sterols by interfering with the activity of cytochrome P450; it damages the fungal cell membrane and changes its permeability, resulting in the loss of important intracellular substances; it can also inhibit fungal triglycerides and phospholipids Biosynthesis; this product can still inhibit the activity of oxidation and peroxidase, causing excessive accumulation of peroxides in cells, resulting in degeneration and necrosis of fungal subcellular structures. Clotrimazole has broad-spectrum antifungal activity, and has good antibacterial effect on Epidermophyton, Trichophyton, Aspergillus, Chromophytes, Cryptococcus and Candida, and has good antibacterial effect on Sporothrix schenckii and Blastomyces dermatitis. , Coccidioides spp., Histoplasma spp. also have certain antibacterial activity. Clotrimazole has good bacteriostatic effect on Candida, Cryptococcus, Aspergillus, algae, dermatophytes, etc. in vivo and in vitro, and its efficacy on superficial skin mycosis is similar to that of griseofulvin. The efficacy of mycosis is similar to that of amphotericin B, and it has a good effect on visceral pathogenic fungi such as Candida albicans, Cryptococcus neoformans, Coccidioides and Histoplasma, etc. It has a better effect on Candida albicans than nystatin. powerful. Fungi are not easy to develop resistance to this product. This product is easily absorbed when taken orally, and can be taken orally to treat systemic and deep fungal infections, such as aspergillus fumigatosis, candidiasis albicans, cryptococcosis, coccidioidomycosis, histoplasmosis (dogs, cats) and fungal sepsis Wait. For severe deep fungal infections, it should be used in combination with amphotericin B. It can also be used externally to treat superficial fungal infections, such as cockscombs and tinea corporis and trichoderma in livestock. Ineffective for tinea capitis. Clotrimazole is also effective against some gram-positive bacteria and Trichomonas vaginalis.

1. Broad-spectrum antifungal drugs. For systemic fungal infections, also externally used for local fungal infections. 2. Antifungal drugs for the treatment of epidermal and deep fungal infections, etc.

Q1.Are you a manufacturer or a trading company
A1.Our company is a leading manufacturer specializing in trade and the development, production and marketing of pharmaceutical intermediates and apis for more than 10 years.
Q2.What about the quality of your products
A2.We value quality as life.We strictly control the quality of each process, established a perfect quality control system.
Q3.In the third quarter.What is your minimum order quantity
A3.Our minimum order quantity is 1 gram.
Q4.Fourth quarter.Can you provide free test samples
A4.Yes, we can provide 10g free samples for consumer test.
Q5.What is your delivery time
A5.Delivery takes 2-3 days, depending on the destination.
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A7.We accept T/T,  Paypal, , money gram, etc.