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BMY7378 inhibitor BMY 7378 2hydrochloride -8-azaspiro[4.5]decane-7,9-dione dihydrochloride
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BMY 7378 DIHYDROCHLORIDE Usage And Synthesis |
Uses | BMY 7378 dihydrochloride is a SR-1A agonist and a selective α1D-AR antagonist. |
Biological Activity | 5-HT 1A partial agonist and high affinity α 1D adrenoceptor antagonist (K i values are 2, 800 and 600 nM at cloned rat α 1D , rat α 1A and hamster α 1B receptors respectively). Also available as part of the α 1 -Adrenoceptor Tocriset™ . |
Biochem/physiol Actions | BMY 7378 dihydrochloride is a partial 5-HT1A serotonin receptor agonist and selective α1D-adrenoceptor antagonist. |
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