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Poly(ethylene glycol) distearate Poly(ethylene glycol) distearate 9005-08-7
About Product Details
Poly(ethylene glycol) distearate Basic information |
Product Name: | Poly(ethylene glycol) distearate |
Synonyms: | DIETHYLENE GLYCOL DISTEARATE;DGD;Polyethyleneglycol3distearate;polyethyleneglycoldistearate#1000;polyglycoldistearate;s1009;s1013;stabogel |
CAS: | 9005-08-7 |
MF: | C19H40O4 |
MW: | 332.5185 |
EINECS: | |
Product Categories: | Cosmetic Ingredients & Chemicals |
Mol File: | 9005-08-7.mol |
Poly(ethylene glycol) distearate Chemical Properties |
Melting point | 35-37 °C |
Fp | >230 °F |
CAS DataBase Reference | 9005-08-7 |
EPA Substance Registry System | Polyethylene glycol distearate (9005-08-7) |
Safety Information |
WGK Germany | 1 |
RTECS | TQ4375000 |
MSDS Information |
Provider | Language |
---|---|
SigmaAldrich | English |
Poly(ethylene glycol) distearate Usage And Synthesis |
Chemical Properties | A soft, off-white solid. PH of 10% dispersion 7.26, saponification number variable. Soluble in chlorinated solvents, light esters, and acetone; slightly soluble in alcohols, insoluble in glycols, hydrocarbons, and vegetable oils. Combustible. |
Uses | POLY(ETHYLENE GLYCOL) (N) DISTEARATE is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry. |
Uses | Pegosperse(R) 300 DS is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry. |
Definition | Distearate ester of polyglycol. |
Production Methods | Polyethylene glycol distearate is prepared by the direct reaction of fatty acids, particularly stearic acid, with ethylene oxide. |
Pharmaceutical Applications | Polyethylene glycol distearate is generally used as emulsifiers in oil-inwater- type creams and lotions. Its hydrophilicity or lipophilicity depends on the number of ethylene oxide units present: the larger the number, the greater the hydrophilic properties. Polyoxyl 40 stearate has been used as an emulsifying agent in intravenous infusions. Polyoxyethylene stearates are particularly useful as emulsifying agents when astringent salts or other strong electrolytes are present. It can also be blended with other surfactants to obtain any hydrophilic–lipophilic balance for lotions or ointment formulations. |
Safety Profile | Poison by intravenous route. When heated to decomposition it emits acrid smoke and irritating fumes. See also POLYETHYLENE GLYCOL. |
Safety | Although Polyethylene glycol distearate is primarily used as emulsifying agents in topical pharmaceutical formulations, certain materials, particularly polyoxyl 40 stearate, have also been used in intravenous injections and oral preparations. Polyethylene glycol distearate has been tested extensively for toxicity in animals(8–13) and are widely used in pharmaceutical formulations and cosmetics. It is generally regarded as essentially nontoxic and nonirritant materials. Polyoxyl 8 stearate (hamster, oral): 27 g/kg (rat, oral): 64 g/kg Polyoxyl 20 stearate (mouse, IP): 0.2 g/kg (mouse, IV): 0.87 g/kg |
storage | Polyoxyethylene stearates are generally stable in the presence of electrolytes and weak acids or bases. Strong acids and bases can cause gradual hydrolysis and saponification. The bulk material should be stored in a well-closed container, in a dry place, at room temperature. |
Incompatibilities | Polyethylene glycol distearate is unstable in hot alkaline solutions owing to hydrolysis, and will also saponify with strong acids or bases. Discoloration or precipitation can occur with salicylates, phenolic substances, iodine salts, and salts of bismuth, silver, and tannins.Complex formation with preservatives may also occur.The antimicrobial activity of some materials such as bacitracin, chloramphenicol, phenoxymethylpenicillin, sodium penicillin, and tetracycline may be reduced in the presence of polyoxyethylene stearate concentrations greater than 5% w/w. |
Regulatory Status | Included in the FDA Inactive Ingredients Database (dental solutions; IV injections; ophthalmic preparations; oral capsules and tablets; otic suspensions; topical creams, emulsions, lotions, ointments, and solutions; and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. |
Poly(ethylene glycol) distearate Preparation Products And Raw materials |
Raw materials | Stearic acid |
About Our Group
Since 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research. Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products. Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation. We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.
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More Product Information
Poly(ethylene glycol) distearate Basic information |
Product Name: | Poly(ethylene glycol) distearate |
Synonyms: | DIETHYLENE GLYCOL DISTEARATE;DGD;Polyethyleneglycol3distearate;polyethyleneglycoldistearate#1000;polyglycoldistearate;s1009;s1013;stabogel |
CAS: | 9005-08-7 |
MF: | C19H40O4 |
MW: | 332.5185 |
EINECS: | |
Product Categories: | Cosmetic Ingredients & Chemicals |
Mol File: | 9005-08-7.mol |
Poly(ethylene glycol) distearate Chemical Properties |
Melting point | 35-37 °C |
Fp | >230 °F |
CAS DataBase Reference | 9005-08-7 |
EPA Substance Registry System | Polyethylene glycol distearate (9005-08-7) |
Safety Information |
WGK Germany | 1 |
RTECS | TQ4375000 |
MSDS Information |
Provider | Language |
---|---|
SigmaAldrich | English |
Poly(ethylene glycol) distearate Usage And Synthesis |
Chemical Properties | A soft, off-white solid. PH of 10% dispersion 7.26, saponification number variable. Soluble in chlorinated solvents, light esters, and acetone; slightly soluble in alcohols, insoluble in glycols, hydrocarbons, and vegetable oils. Combustible. |
Uses | POLY(ETHYLENE GLYCOL) (N) DISTEARATE is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry. |
Uses | Pegosperse(R) 300 DS is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry. |
Definition | Distearate ester of polyglycol. |
Production Methods | Polyethylene glycol distearate is prepared by the direct reaction of fatty acids, particularly stearic acid, with ethylene oxide. |
Pharmaceutical Applications | Polyethylene glycol distearate is generally used as emulsifiers in oil-inwater- type creams and lotions. Its hydrophilicity or lipophilicity depends on the number of ethylene oxide units present: the larger the number, the greater the hydrophilic properties. Polyoxyl 40 stearate has been used as an emulsifying agent in intravenous infusions. Polyoxyethylene stearates are particularly useful as emulsifying agents when astringent salts or other strong electrolytes are present. It can also be blended with other surfactants to obtain any hydrophilic–lipophilic balance for lotions or ointment formulations. |
Safety Profile | Poison by intravenous route. When heated to decomposition it emits acrid smoke and irritating fumes. See also POLYETHYLENE GLYCOL. |
Safety | Although Polyethylene glycol distearate is primarily used as emulsifying agents in topical pharmaceutical formulations, certain materials, particularly polyoxyl 40 stearate, have also been used in intravenous injections and oral preparations. Polyethylene glycol distearate has been tested extensively for toxicity in animals(8–13) and are widely used in pharmaceutical formulations and cosmetics. It is generally regarded as essentially nontoxic and nonirritant materials. Polyoxyl 8 stearate (hamster, oral): 27 g/kg (rat, oral): 64 g/kg Polyoxyl 20 stearate (mouse, IP): 0.2 g/kg (mouse, IV): 0.87 g/kg |
storage | Polyoxyethylene stearates are generally stable in the presence of electrolytes and weak acids or bases. Strong acids and bases can cause gradual hydrolysis and saponification. The bulk material should be stored in a well-closed container, in a dry place, at room temperature. |
Incompatibilities | Polyethylene glycol distearate is unstable in hot alkaline solutions owing to hydrolysis, and will also saponify with strong acids or bases. Discoloration or precipitation can occur with salicylates, phenolic substances, iodine salts, and salts of bismuth, silver, and tannins.Complex formation with preservatives may also occur.The antimicrobial activity of some materials such as bacitracin, chloramphenicol, phenoxymethylpenicillin, sodium penicillin, and tetracycline may be reduced in the presence of polyoxyethylene stearate concentrations greater than 5% w/w. |
Regulatory Status | Included in the FDA Inactive Ingredients Database (dental solutions; IV injections; ophthalmic preparations; oral capsules and tablets; otic suspensions; topical creams, emulsions, lotions, ointments, and solutions; and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. |
Poly(ethylene glycol) distearate Preparation Products And Raw materials |
Raw materials | Stearic acid |
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