for Antibacerial 99% High Quality by HPLC Hot Sale! Factory Supply High Quality Rifampicin Raw Materials CAS 13292-46-1

Superiority:

Product Name: Rifampicin
Synonyms: 9,17,19,21-hexahydroxy-23-methoxy-2,4,12,1///;2,7-(epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2-h)-dione,5,6;3-(((4-methyl-1-piperazinyl)imino)methyl)-rifamyci;3-((4-methyl-1-piperazinyl)iminomethyl)rifamycinsv;8-(((4-methyl-1-piperazinyl)imino)methyl)rifamycinsv;8-(4-Methylpiperazinyliminomethyl)rifamycinSV;8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins
CAS: 13292-46-1
MF: C43H58N4O12
MW: 822.94
EINECS: 236-312-0
Melting point: 183°C (dec.)
Boiling point: 761.02°C
Storage temp.: 2-8°C

Description:

Rifampicin is a semisynthetic derivative of rifamicin B, a macrolactam antibiotic and one of more than five antibiotics from a mixture of rifamicins A, B, C, D, and E, which is called a rifamicin complex, which is produced by actinomycetes Streptomyces mediteranei (Nocardia mediteranei). It was introduced into medical practice in 1968. Synthesis of rifampicin begins with an aqueous solution of rifamicin, which under the reaction conditions is oxidized to a new derivative of rifamicin S, with the intermediate formation of rifamicin O. Reducing the quinone structure of this product with hydrogen using a palladium on carbon catalyst gives rifamicin SV. The resulting product undergoes aminomethylation by a mixture of formaldehyde and pyrro lidine, giving 3-pyrrolidinomethylrifamicin SV. Oxidizing the resulting product with lead tetracetate to an enamine and subsequent hydrolysis with an aqueous solution of ascorbic acid gives 3-formylrifamicin SV. Reacting this with 1-amino-4-methylpiperazine gives the desired rifampicin.

Usage:

Semisynthetic antibiotic. Antibacerial (tuberculostatic)

1. Broad-spectrum antibiotics. It has bacteriostatic or bactericidal effects on Mycobacterium tuberculosis, Gram-positive bacteria and some Gram-negative bacteria. It is mainly used for the infection of drug-resistant tuberculosis plant bacteria and drug-resistant Staphylococcus aureus, and also has a certain curative effect on leprosy.

2. It is a broad-spectrum antibiotic and can enter into cells. It is a full-effect bactericidal drug with strong bactericidal power.

3. It is a broad-spectrum antibiotic with strong bactericidal effect on Mycobacterium and Gram-positive and negative bacteria

4. Used as a pharmaceutical intermediate

5. Broad-spectrum antibiotics. It has bacteriostatic or bactericidal effects on Mycobacterium tuberculosis, Gram-positive bacteria and some Gram-negative bacteria. It is mainly used for the infection of drug-resistant tuberculosis plant bacteria and drug-resistant Staphylococcus aureus, and also has a certain curative effect on leprosy. It is a broad-spectrum antibiotic and can enter into cells. It is a full-effect bactericidal drug with strong bactericidal power. It has good antibacterial activity against Gram-positive cocci and Mycobacterium tuberculosis, and the antibacterial spectrum is the same as that of rifampicin

6. It has a broad-spectrum antibacterial effect, and has good antibacterial activity against Gram-positive cocci and Mycobacterium tuberculosis. The antibacterial spectrum is the same as that of rifampicin.

7. APIs (anti-tuberculosis antibiotics)

8. Inhibits DNA recombination and protein insertion into mature virus particles. Inhibits initiation of RNA synthesis by binding to the β-subunit of RNA polymerase.

Orange red flake crystal or brick red crystal powder. Decomposes at 183-188°C. Soluble in chloroform and dimethyl sulfoxide, soluble in ethyl acetate, methanol and tetrahydrofuran, soluble in water (pH<6), propanol and carbon tetrachloride. The dry powder can be stable for more than 5 years, and its aqueous solution fails at room temperature for 10 hours, but adding a reducing agent (such as ascorbic acid) can reduce the decomposition, and it is extremely stable in dimethyl sulfoxide.

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