ISO Certified Reference Material High Quality Promestriene Powder CAS 39219-28-8

Superiority:

Promestriene is a kind of special estradiol diether with its special molecular structure making it cause the biological effects in situ without the necessity of exerting the effect after being metabolized. It has a biological half-life of being smaller than 24 h. Therefore, upon vaginal administration, drug will directly take effect on the vaginal mucosa without being absorbed by the mucosa. There is no accumulation of estrogen in the body, particularly in the estrogen-sensitive organs far away from the vagina.
Clinical observation further noted that the topical administration of promestriene has no effect on the plasma sex hormone binding globulin (SHBG), estrone (E1), estradiol (E2), estriol (E3), LH and FSH, and can effectively prevent and treat the atrophic vaginitis with strict local estrogen effect.

Prostriene, Gengbaofen (Prostriene Soft Capsules and Creams) and Kebojing (Chloroquinado/Prostriene Vaginal Tablets) have been collected by the Martindale Drug Manual and have been clinically used in more than 40 countries abroad for 40 years. For more than a few years, it is still the first-line drug for the treatment of vaginal infection and atrophic vaginitis in many countries. Clinical practice shows that it is safe and effective, and the patients are well tolerated. Promestriene is a special estradiol diether, and its special molecular structure enables it to have biological effects in situ without metabolism, and its biological half-life is less than 24h. Therefore, for vaginal administration, the drug directly acts on the vaginal mucosa and is not absorbed by the mucosal tissue, and estrogen does not accumulate in the body, especially in the estrogen-sensitive organs far away from the vagina. The clinical observation further pointed out that the topical use of proestene has no effect on plasma sex hormone binding protein (SHBG), estrone (E1), estradiol (E2), estriol (E3), LH, and FSH, and can effectively Prevention and treatment of atrophic tract inflammation with strict local estrogenic action. Compared with other drugs, the advantage of prostriene is that it is hardly absorbed through the vagina, so it can effectively avoid the systemic risks brought about by long-term vaginal local estrogen supplementation, and there are fewer adverse reactions, and it is less severe and has no systemic effects. It has mild side effects and high safety. Most patients are willing to accept it. It is a good choice for the current treatment of atrophic vaginitis, especially for those patients with estrogen-dependent diseases.

This product is a chemically synthesized steroid estrogen. It mainly acts on the vaginal mucosa locally. It thickens the mucosa, balances the pH of the vagina, improves the vaginal environment, enhances the resistance of vaginal tissues, reduces vaginal infection, and has a good effect on improving atrophy. The role of local symptoms of vulvar and vaginal vaginitis, which produces local estrogenic effects on the mucosa at the bottom of the female genital tract. This product is topical and does not produce systemic estrogenic effects on organs remote from the vagina after intravaginal use.