High Quality Pharmaceutical Intermediate Trametinib Anti Cancer Factory Supply High Purity CAS 871700-17-3

High Quality Pharmaceutical Intermediate Trametinib Anti Cancer Factory Supply High Purity CAS 871700-17-3

Min.Order / FOB Price:Get Latest Price

1 Gram	FOB Price:USD 0.0200 -0.0300

1 Gram

FOB Price:USD 0.0200 -0.0300

Min.Order :1 Gram
Purity: 99%+
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Trametinib TrametinibTrametinib CAS 871700-17-3

Quick Details

Appearance:White to off-white powder
Application:Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibitory activity against c-Raf, B-Raf, ERK1/2.
PackAge:bag or barrel or drum
ProductionCapacity:6000|Kilogram|Day
Storage:Store at room temperature
Transportation:by express or air or sea

Superiority:

1, We offer competitive factory price for both wholesalers and retailers.
2, Fast reply for inquiries.
3, Stable Quality, high purity.
4, We offer EXW/FOB/CFR/DAP/DDP trade terms for your option.
5, Fast Delivery for shipment and Safe for destination custom clearance.
6, Free samples.
7, Free custom clearance with freight prepaid, delivery door to door.
8, More than 22 years export experience in this field.

Description:

Trametinib (trade name Mekinist) is a cancer drug. It is a MEK inhibitor drug with anti-cancer activity.

Trametinib(Mekinist) is a reversible, highly selective, allosteric inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activation and kinase activity. MEK proteins are components of the extracellular signal-related kinase (ERK) pathway. In melanoma and other cancers, this pathway is often activated by mutated forms of BRAF which activates MEK. Trametinib inhibits activation of MEK by BRAF and inhibits MEK kinase activity. Trametinib inhibits growth of BRAF V600 mutant melanoma cell lines and demonstrates anti-tumor effects in BRAF V600 mutant melanoma animal models.

Mekinist is indicated as monotherapy or in combination with Tafinlar (dabrafenib) for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation.

Usage:

Used in the systematic treatment of advanced cutaneous melanoma. An EGFR kinase inhibitor.

English name: Trametinib

CAS number: 871700-17-3

Molecular formula: C26H23FIN5O4

Molecular weight: 615.39

Melting point: 300-301°C

Density: 1.74

Storage conditions: -20°C

Solubility:Soluble in DMSO(upto20mg/ml)

Form: White solid.

Acidity coefficient: (pKa) 14.76±0.70 (Predicted)

Color:White

Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibitory activity against c-Raf, B-Raf, ERK1/2.

Details:

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together. Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.

1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions.
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.

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