ISO Certified Factory Price 7-Amino-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Diphenylmethyl Ester Chemical CAS 36923-21-4

ISO Certified Factory Price 7-Amino-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Diphenylmethyl Ester Chemical CAS 36923-21-4

Min.Order / FOB Price:Get Latest Price

1 Gram	FOB Price:USD 0.0200 -0.0300

1 Gram

FOB Price:USD 0.0200 -0.0300

Min.Order :1 Gram
Purity: 99%+
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

7-Amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester 7-NACABH 7-NACABH/NAM

Quick Details

Appearance:White powder
Application:Cefbutan, also known as cefbutan, chemical name is 7β-[2-(2-amino-4-thiazolyl)-4-carboxy-2-(Z)-butenamido]-3-cephem -2-Carboxylic acid, a third-generation oral cephalosporin, has broad-spectrum antib
PackAge:bag or barrel or drum
ProductionCapacity:6000|Metric Ton|Day
Storage:Store at room temperature
Transportation:by express or air or sea

Superiority:

Product Name	7-Amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester
CAS NO.	36923-21-4
Appearance	White Powder
Purity	99%+
Melting point	164-168°C
Boiling point	587.8±50.0 °C(Predicted)
Density	1.39 g/cm3(Predicted)
Application	APIs; pharmaceutical intermediates; pharmaceutical raw materials
Chemical structure
Usage	It is mainly used to prepare ceftibutene
Storage	Normal Temperature

The parent nucleus of ceftibuten is mainly used for the preparation of cefbutene, and the details are as follows: a preparation method of cefbuten, firstly, the parent nucleus of ceftibuten and the side chain of ceftibuten are subjected to acylation reaction to obtain double-protected cefbuten, and then The protective group is removed through the deprotection group reaction, and the deprotected group reaction solution is extracted, washed and decolorized, and then subjected to isoelectric point crystallization to obtain a crude ceftibuten product, which is further refined to obtain ceftibuten. The preparation method provided by the invention has a simple synthetic route, and the treatment method for the deprotection group reaction solution is easy to operate, can remove most of the impurities, and finally obtains a ceftibuten product with high yield and high purity. The results of the examples show that the HPLC purity of the preparation method provided by the present invention of ceftibuten can reach 99.2%, and the molar yield of the product is 57.6%.

Cefbutan, also known as cefbutan, chemical name is 7β-[2-(2-amino-4-thiazolyl)-4-carboxy-2-(Z)-butenamido]-3-cephem -2-Carboxylic acid, a third-generation oral cephalosporin, has broad-spectrum antibacterial activity, has strong antibacterial effect on most Gram-negative bacilli and some positive cocci, and has a strong antibacterial effect on plasmid-mediated β-lactamase It is highly stable and has anti-biotic aftereffects. According to the estimate of the China Pharmaceutical Business Association, the current domestic sales of cephalosporins is close to 20 billion yuan. Due to the prosperity of the cephalosporin drug market, the demand for 7-ACA, 7-ADCA, 7-NACABH and other cephalosporin parent nuclei in production has increased; and in view of the situation that the production of penicillin industrial salt in my country has fallen into a serious surplus in recent years, The only way out of its excess penicillin industrial salt is that it can be converted into downstream derivative products with extremely high added value, among which the most promising products are 7-NACABH, 7-ACCA and 7-ANCA. Intermediate.

Details:

Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together. Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.

Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.

An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.

1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.

2.We can provide you with ten thousands of products of different levels.

3. We offer convenient one-station purchasing service.

(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.

Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.

The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions.
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.

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