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Eplerenone Eplerenone for peak identification (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylicacidγ-lactoneMethylester
Eplerenone is a new type of selective aldosterone receptor antagonist. It was approved for clinical use by the National Food and Drug Administration in 2002. The pure product is white or off-white crystals. Its antagonistic effect on aldosterone is stronger than that of spirnolactone. The affinity with progesterone receptors is extremely low, the side effects are small, and it has a definite effect on the treatment of hypertension, heart failure and myocardial infarction, with fewer side effects and good tolerability. It is a good substitute for spirnolactone.
For severe hypertension that cannot be controlled by the combination of a variety of antihypertensive drugs, the addition of eplerenone can significantly reduce blood pressure, especially systolic blood pressure. Combined treatment with angiotensin converting enzyme inhibitor (ACEI) and β-receptor blockers can improve the quality of life and reduce mortality in patients with severe heart failure and myocardial infarction.
1.Organic synthetic raw materials, mainly used in the synthesis of cationic etherifying agents, emulsification, solubilization, dispersion, wetting in pharmacy, and flotation agent in synthesis. Reagents for the determination of methoxy and ethoxy groups.
2.Precautions for safe operation
Avoid contact with skin and eyes. Prevent the formation of dust and aerosols.
Where there is dust generation, provide suitable exhaust equipment.
3.Conditions for safe storage, including any incompatibilities
Store in a cool place. Keep the container tightly closed and store in a dry and ventilated place.
Density 1.3±0.1 g/cm3
Boiling point 597.9±50.0 °C at 760 mmHg
Melting point 241-243ºC
Molecular formula C24H30O6
Molecular weight 414.491
Flash point 259.5±30.2 °C
Accurate quality 414.204254
PSA 82.20000
LogP 1.05
Appearance white solid
Vapor pressure 0.0±1.7 mmHg at 25°C
Refractive index 1.587
1. Cardiotonic
2. Antihypertensive drugs have the characteristics of strong selectivity to aldosterone receptors, good antihypertensive effect and long-lasting effect, and can reverse or reduce many adverse effects of aldosterone on cardiovascular.
Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together. Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.
Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.
An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.
1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.
2.We can provide you with ten thousands of products of different levels.
3. We offer convenient one-station purchasing service.
(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.
Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.
The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions.
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.
Product Name:Citalopram hydrobromide
CAS:59729-32-7
MF:C20H22BrFN2O
MW:405.3
EINECS:261-890-6
Mol File:59729-32-7.mol
Melting point:182-188°C
Flash point:9oC
storage temp. -20°C Freezer
solubility H2O: soluble (sparingly)
form powder
We are at the exhibition every year.
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