Zhaojun Supply 100% Natural Extract Artesunate 88495-63-0

Details:

Basic Information:

Product Description:
Artesunate is used primarily as treatment for malaria; it has also been shown to be >90% efficacious at reducing egg production in Schistosoma haematobium infection.
According to WHO intravenous AS is the drug of choice for severe malaria both in children and adults where there is low transmission.In regions where transmission is high, randomized trials among Asian adults and African children strongly advocates the use of artesunate over quinine as the treatment of choice for falciparum malaria.

Application Area:
Artesunate is prepared from dihydroartemisinin (DHA) by reacting it with succinic acid anhydride in basic medium. Pyridine as base/solvent, sodium bicarbonate in chloroform and catalyst DMAP (N,N-dimethylaminopyridine) and triethylamine in 1,2-dichloroethane have been used, with yields of up to 100%. A large scale process involves treatment of DHA in dichloromethane with a mixture of pyridine, a catalytic amount of DMAP and succinic anhydride. The dichloromethane mixture is stirred for 6-9 h to get artesunate in quantitative yield. The product is further re-crystallized from dichloromethane. alpha-Artesunate is exclusively formed (m.p 135-137C).
Artesunate is an antimalarial agent. It is a water-soluble hemisuccinate derivative of dihydroartemisinin. Artemisinin is a sesquiterpene lactone isolated from Artemisia annua, a herb that has traditionally been used in China for the treatment of malaria. Artesunate and its active metabolite dihydroartemisinin are potent blood schizonticides, active against the ring stage of the parasite. Artesunate is ideal for the treatment of severe malaria, including cerebral malaria. It is also active against chloroquine and mefloquine resistant strains of P. falciparum.
It is unstable in neutral solution and is therefore only available for injections as artesunic acid. The injectable formulation must be prepared immediately before use in 5% (w/v) sodium bicarbonate solution to produce the salt sodium artesunate

FAQ
Application Area:
Uridine 5-Mophosphate Disodium are produced through the hydrolytic reaction from Ribonucleic acid(RNA) as raw material by enzymatic catalysis to form four kinds of nucleotides 5- 'AMP (adenosine-5'-monophosphate), 5'-GMP•2Na(guanosine-5'-monophosphate, disodium salt), 5'-CMP(cytidine-5'-monophosphate)-, 5'-UMP•2Na (uridine- 5'-monophosphate,Disodium salt) .By the chromatographic isolation, four kinds of separated 5'-nucleotide products with high purity can be obtained. These products can be widely applied in medicine, reagent, fine chemical industry, and additive of food fields etc.

1:  How to start orders or make payments

You can send your Purchase order, or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma
Invoice with our bank details for your confirmation, then you can make payment accordingly.

2:  How to make the payment
We can accept L/C, T/T, West Union, Money Gram etc.

3: What's your MOQ
For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low price product, our MOQ starts from 100g and 1kg.

4:  When will you deliver the goods
If we have inventory, generally we can arrange shipment after receipt of payment 2 to 3 days. If not, it will be decided by the time of the factory production.


Our advantages
1.High quality with competitive price.
2. All purity>99%.
3. We are manufacturer and can provide high quality products with factory price.
Fast and safe delivery.

1. Parcel can be sent out in 24 hours after payment tracking number available.
2. Secure and discreet  shipment verious transportation methods for your choice.
3. Customs pass rate >99%.
4. We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

We have clients throughout the world.
1. Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2. Market feedback and goods feedback will be appreciated , meeting customers' requirement is our responsibility.
3. High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
5.Sample order are welcome.
6.NMR,HPLC and COA can be supplied
7.We can supply sample for testing
8.We promise 100% deliveried,and 100% resend or refunds if parcel is not deliveried!