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Ambroxol hydrochloride Ambroxol HCl Lower Price Ambroxol hydrochloride
Name | Ambroxol HCl |
CAS | 23828-92-4 |
Boiling Point | 468.6ºC at 760 mmHg |
---|---|
Melting Point | 235 - 240ºC |
Molecular Formula | C13H19Br2ClN2O |
Molecular Weight | 414.564 |
Flash Point | 237.2ºC |
Exact Mass | 411.955261 |
PSA | 58.28000 |
LogP | 4.96100 |
English name: Ambroxol hydrochloride CAS number: 23828-92-4 Molecular formula: C13H19Br2ClN2O Molecular weight: 414.56 EINECS Number: 245-899-2
1. The application of ambroxol hydrochloride in the respiratory system can increase the secretion of serous fluid in the airway, dilute the sputum and make it easier to discharge, thereby improving the respiratory condition, so that the PS of the respiratory mucosa can play a normal protective role; at the same time, it also has the function of pulmonary Its high affinity can promote the synthesis and secretion of PS in the lungs, thereby maintaining the stability of alveoli, which is beneficial to the improvement of alveolar function. Therefore, early application of ambroxol hydrochloride can relieve airway obstruction, improve ventilation, shorten the course of disease, and reduce various complications. It is often used for the treatment of chronic bronchitis, asthmatic bronchitis, pneumonia, and lung abscess. 2. Application in senile chronic obstructive pulmonary disease (COPD) COPD is a common disease of the respiratory tract. With the increase of age, the airway ciliary clearance function of the elderly gradually declines, and the antioxidant effect of the lung decreases. Ambroxol has anti-inflammatory, antioxidant and increased ciliary movement and other effects, which can improve the clearance function of the airway epithelial surface, thereby preventing The occurrence of COPD. 3. Clinical application in neonatal respiratory system Neonatal respiratory distress syndrome (NRDS) is due to lack of pulmonary surfactant (PS). Ambroxol can promote the biosynthesis and secretion of endogenous PS, increase the release of endogenous PS from alveolar type II cells, thereby reducing the surface tension of alveoli, re-inflating the atrophied alveoli, thereby improving lung function, shortening the duration of mechanical ventilation and Oxygen therapy time can reduce the risk factors of bronchopneumonia. 4. Lung protection after cardiopulmonary bypass (CPB) Lung injury after cardiopulmonary bypass is the most common complication after cardiothoracic surgery. Foreign studies have confirmed that after ischemia-reperfusion injury in the lung after CPB, neutrophils and platelets are activated, aggregate in the lung, adhere to the inner wall of pulmonary capillaries, release a large number of oxygen free radicals, inflammatory mediators, and damage alveolar type II cells and blood vessels. Endothelial cells, resulting in reduced release of PS synthesis. In addition, the increased permeability of alveolar-capillary membrane, the accumulation of fluid in the alveoli, the excessive consumption of PS, and the inability to exert normal physiological effects, increase the surface tension of the alveoli, and the alveoli tend to collapse, leading to respiratory disorders. Ambroxol hydrochloride can effectively promote the synthesis and secretion of PS after thoracic surgery, inhibit the response of activated neutrophils, reduce airway resistance and airway hyperresponsiveness, affect airway wall ion transport and potential difference, and reduce cardiopulmonary bypass surgery. Post-lung injury.
1. An effective neuronal sodium ion channel inhibitor, inhibits anti-TTX sodium ion current, phase block, IC50 is 22.5 μM, inhibits TTX-sensitive sodium ion current, IC50 is 100 μM. 2. Cough medicine 3. Antitussive and expectorant, used for the expectorant treatment of acute and chronic respiratory diseases, especially chronic bronchitis.Our Advantages:
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Product Name Ceftizoxime
CAS NO. 68401-81-0
Purity 99%
Melting point 227 C(dec.)(lit.)
Appearance and shape White powder
Molecular formula: C13H14N5NaO5S2
Molecular weight: 407.39
EINECS Number: 629-729-8
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