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β-Nicotinamide Adenine Dinuclotide beta-Diphosphopyridine nucleotide NAD+
English name: β-Nicotinamide adenine dinucleotide
CAS Number: 53-84-9
Molecular formula: C21H27N7O14P2
Molecular weight: 663.43
EINECS Number: 200-184-4
Melting point: 140-142°C (decomp)
Specific rotation: D20-31.5°(c=1.2 in water)
Storage conditions: -20°C Solubility H2O: 50mg/mLNicotinamide adenine dinucleotide (abbreviated as NAD), also known as pyridine diphosphate (abbreviated as DPN), or co-dehydrogenase I or coenzyme I. There are two states of oxidized (NAD+) and reduced (NADH) in mammals. The oxidized (NAD+) has a maximum ultraviolet absorption spectrum at 260nm, and through various deaminases, it accepts a hydrogen atom from the substrate and One electron, which becomes the reduced form (NADH), has an absorption maximum at 340 nm. β-Nicotinamide adenine dinucleotide is used as a coenzyme in redox reactions, as a donor of the ADP ribose moiety in ADP ribosylation reactions, and as a precursor of the second messenger molecule cyclic ADP ribose. Beta-nicotinamide adenine dinucleotide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins, which use NAD+ to remove acetyl groups from proteins.
1. It is a necessary coenzyme in the body, used for biochemical research, clinical diagnosis, clinical drug and drug research. 2. Coenzyme drugs. Clinically, it is mainly used for the adjuvant treatment of coronary heart disease, which can improve symptoms such as chest tightness and angina pectoris. Adverse reactions occasionally dry mouth, dizziness, nausea and so on. 3. Participate in energy metabolism and material metabolism in the body, which is beneficial to the repair and renewal of cells. For coronary heart disease, myocarditis, leukopenia embolism treatment. 4. Nicotinamide adenine dinucleotide is a coenzyme that transfers protons (more precisely, hydrogen ions), and it appears in many metabolic reactions in cells. NADH or more precisely NADH+H+ is its reduced form. It can be reduced, carrying up to two protons (written as NADH+H+). NAD+ is a coenzyme for dehydrogenases, such as alcohol dehydrogenase (ADH), used to oxidize ethanol. It plays an irreplaceable role in glycolysis, gluconeogenesis, tricarboxylic acid cycle and respiratory chain. The intermediate product will give off the hydrogen to NAD, making it NADH+H+. NADH+H+ will act as the carrier of hydrogen to synthesize ATP by chemical osmotic coupling in the respiratory chain.
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