Anti Cancer Peptide Pnc-27/Pnc27 5mg/Vial Powder

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1 box	Negotiable

1 box

Negotiable

Min.Order :1 box
Purity: 99
Payment Terms : L/C,T/T,

Keywords

Pnc-27 Pnc27 Pnc27 peptide

Quick Details

Appearance:white
Application:peptides
PackAge:drum
ProductionCapacity:100|bottle|Day
Storage:room
Transportation:

Superiority:

name: PNC-27
Molecular formula: C84H128N18O24
Molecular weight: 1772.93
Purity: >98.0%
Specication : 5mg/vial, 10vials/box

Details:

Anti Cancer Peptide Pnc-27/Pnc27 5mg/Vial Powder

PNC-27 is a peptide that contains p53 protein amino acid residues 12-26 of its HDM-2 binding domain attached to a transmembrane-penetrating sequence, also called the membrane residency peptide (MRP). Both PNC-27 and PNC-28 (which has a sequence that is identical to that of PNC-27 but lacks the first six amino acid residues of PNC-27 (i.e., p53 residues 17-26) are lethal to a wide variety of cancer cells with IC50 values ranging from around 75 ug/ml (18.6 uM) to 200 ug/ml (50 uM). On the other hand, neither peptide affects normal or untransformed cells in culture, including human hematopoietic stem cells even at the highest doses (around 500 ug/ml) tested. The latter finding suggests that both peptides would not be toxic to bone marrow function in contrast to the effects of many chemotherapeutic agents.