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10 Kilogram |
Negotiable |
High Quality Organic Oxyresveratrol CAS 29700-22-9 high quality Organic Oxyresveratrol High purity Organic Oxyresveratrol
Molecular Formula | C14H12O4 |
Molar Mass | 244.24 |
Density | 1.468±0.06 g/cm3(Predicted) |
Melting Point | 201-202.5 °C |
Boling Point | 523.8±30.0 °C(Predicted) |
Flash Point | 260.9°C |
Solubility | DMSO : ≥ 34 mg/mL (139.21 mM) |
Vapor Presure | 1.37E-11mmHg at 25°C |
Appearance | White-like powder |
Color | Pale Yellow to Pale Beige |
pKa | 9.14±0.10(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.8 |
MDL | MFCD11974969 |
Physical and Chemical Properties | White-like powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Polygonum cuspidatum. |
In vitro study | Oxysveratrol inhibits amyloid beta-induced neurotoxicity, the in vitro activity of β-secretase, in cultured cortical neurons. In Cultured neuronal cells, neurotoxicity and DNA damage can also be prevented by its antioxidant activity. Oxysveratrol has moderate inhibitory activity against H5N1 neuraminidase. However, it has a strong inhibitory effect on α-glucosidase, an enzyme responsible for breaking down starch and polysaccharides into glucose in the intestinal tract. Oxyresveratrol is an effective radical scavenger. Oxysveratrol protects hepatocytes from oxidative stress, mitochondrial damage, and synthetic cell death. It can induce the activation of antioxidant transcription factor Nrf2 by ERK phosphorylation. |
In vivo study | Oxysveratrol is extensively metabolized in the liver and rapidly eliminated by urination, so its short half-life in vivo limits its clinical application. In addition, its potential protective effect against neurodegenerative diseases is also hampered by its weak ability to penetrate the blood-brain barrier. Although the inhibitory activity against HSV-1 was weak in vitro, oxysveratrol, as an external emulsion, had high therapeutic efficacy in the mouse skin infection HSV1 model. Oxyresveratrol can ameliorate ccl4-induced acute liver injury. |
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