Details:

Product  Description：

Molecular Formula	C35H40Cl2N4O6
Molar Mass	683.62
Melting Point	157-163°; mp 174-180°; mp 167-170°
Boling Point	722°C at 760 mmHg
Flash Point	390.4°C
Water Solubility	Soluble in DMSO. Slightly soluble in water and ethanol/n
Solubility	DMSO 21 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Vapor Presure	1.07E-20mmHg at 25°C
Appearance	solid
Color	White
Merck	14,5743
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
In vitro study	At a sustained potential of − 37 mV, the calcium ion concentration response curve was inhibited by Ca manipine at concentrations above 0.1 nM. Manipine inhibited coronary and renal arteries with pIC50 of 9.3 nM and 9.1 nM, respectively. Manipipine partially inhibits sympathetic activity and inhibits the mean arterial pressure response to infusion of norepinephrine. Manidipin also inhibits aldosterone secretion. Manipipine increases urinary calcium and uric acid. In addition, manidipin, at nanomolar concentrations, is able to effectively regulate gene transcription involved in pro-inflammatory changes in mesangial cells.
In vivo study	Manidipine (3 mg/kg and 10 mg/kg, p.o.) dose-dependently reduced systolic blood pressure in three types of hypertensive rats. At a dose of 10 mg/kg, manipipine is able to reduce blood pressure to normal levels from 1 hour to 3 hours after administration; The antihypertensive effect lasts at least 8 hours. When manidipin was administered at 10 μg/kg, the hypotensive effect was significantly enhanced. Manidipin effectively inhibited the calcium ion flux induced by depolarization to 0 mV. However, a low concentration of manipine (1-3 nM) enhanced the flux of calcium ions induced by a -20 mV depolarizing pulse with a resting-state membrane potential of -80 mV. The inhibition of calcium ion flux by manidipin develops slowly and requires 10 minutes for maximum inhibition.

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Company Profile：

 

Wuhan Han Sheng New Material Technology Co. Ltd is a professional company which specialized in manufacturing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents.

We have long term cooperation pharmaceutical raw material production plant and a reagent research and development center, with a rich professional background and strong competitive advantage. We have a professional and experienced team and we promise clients to provide the best quality, price and service. During the business cooperation with clients, we always adhere principle of Honesty, Trustworthiness and win-win policy. We guarantee 100% qualification of our products pass through the standard of USA, Mexico, UK, Australia, Canada, Brazil, France, Germany, Spain, Belgium, Sweden, the Netherlands and so on.

 

 

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Exhibitions:

 

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Products & Packaging：

 

Our products are used for pharmaceuticals, pesticides, synthetic dyes, organic chemicals, inorganic chemicals, coatings, spices and essence, cosmetics and toilet products, soaps and synthetic detergents, surfactants, printing inks and their auxiliaries, adhesives, photosensitive materials, magnetic materials, catalysts, reagents, water treatment agents and polymer flocculants, papermaking auxiliaries, leather auxiliaries, synthetic materials auxiliaries, textile printing and dyeing agents and finishing agents, food additives Feed additives, animal drugs, etc.

 

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About  Us 

 

 

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Shipment & Payment：

 

*small quantity: By Fedex, DHL, HKPOST, UPS, TNT or As customers’ requirement

*Bulk order: By air or sea

*Delivery: within 3 days for samples and 10 days for bulk order

 

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Our Markets: 

 

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FAQ

 

1. Are you a trade company or factory

We are a factory with our own trading company.

 

2. How do you control the quality

Our factory is equipped with professional technicians to inspect the quality around production lines. The inspection test would be made every 2 hours to ensure the production conform to quality standard. We also accept BV, SGS, or any third pary inspection.

3. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

4. Where is your factory located How can I visit the factory

Our factory located in Hebei, China

 

5. Can I get some samples

Yes, we can supply sample with free, but the shipping cost be paid by our customers.

 

6. How to start orders or make payments

Proforma Invoice will be issued first after confirmation of order, enclosed our bank information. Payment could be done by T/T or .

 

7. How to confirm the product quality before placing order

You can get free samples for some products. You only need to pay the shipping cost or arrange a courier to us and take the samples.

 

8. How do you treat quality complaint

First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.