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factory supply GMP,DMF,CEP Cefixime
factory supply GMP,DMF,CEP Cefixime
factory supply GMP,DMF,CEP Cefixime
factory supply GMP,DMF,CEP Cefixime

factory supply GMP,DMF,CEP Cefixime

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: USP/EP/BP
  • Payment Terms : L/C,T/T,Other

Keywords

Cefixime CEFIXME TRIHYDRATE 79350-37-1

Quick Details

  • Appearance:White crystallization
  • Application:Reaction properties,Immunosuppressive effect,anti- Virus response
  • PackAge:1kg/tin
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:
  • Transportation:AIR SEA TRAIN

Superiority:

We are very compeitive on Cefixime.Our mfr is GMP certified for this item with CEP document. 

Product Name: Cefixime
CAS: 79350-37-1
MF: C16H15N5O7S2
MW: 453.45
EINECS: 616-684-4
Product Categories: Pharmaceutical intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Heterocycles;cephalosporins
Mol File: 79350-37-1.mol
Cefixime Structure

Details:

Cefixime Usage And Synthesis
Cephalosporin antibiotics Cefixime is a third-generation oral cephalosporin antibiotic, also known as Oroken, Suprax, Cefspan, in clinic used for the treatment of bacterial infectious diseases caused by Streptococcus (except Enterococci), Pneumonia chain, Neisseria gonorrhoeae, Escherichia coli, Branhamella catarrhalis, Serratia bacteria, Citrobacter, Enterobacter cloacae, Enterobacter aerogenes, Haemophilus influenzae, Klebsiella, Serratia, Proteus and Haemophilus Influenzae, etc. the indications are as follow:
1. respiratory infections, such as pneumonia, tonsillitis, pharyngitis, bronchiectasis (infection), secondary infection of chronic respiratory infectious diseases ,acute and chronic bronchitis, etc.
2. urinary and reproductive tract infections, such as gonococcal urethritis, cervicitis, pyelonephritis, cystitis, gonorrhea , etc.
3. intra-abdominal infections (including cholecystitis, cholangitis, peritonitis).
4. scarlet fever, otitis media, sinusitis and so on.
Mechanism of action Antibacterial mechanism of action in Cefixime is similar to other third-generation cephalosporins, through combined with one or more penicillin-binding proteins (PBPs), inhibits cell wall synthesis of bacterial dividing cells. PBPs is located in the cytoplasmic membrane of bacteria, possibly is catalyzing enzyme of bacterial cell wall synthesis last phase. The role of the results of this product is to make the bacteria form defective cell wall which is unstable for osmotic pressure, thereby having an antibacterial effect. Different strains have their own unique PBPs. Different affinity of Cefixime on different PBPs is the main factor affecting its activity of antibacterial spectrum.
Drug Interactions 1. in combination with aminoglycoside antibiotics have synergistic antibacterial effect on certain sensitive strains.
2. there are reports that aspirin may increase the blood concentration of Cefixime.
3. in combination with aminoglycosides or other cephalosporins will increase the renal toxicity.
4. in combination with strong diuretics such as furosemide can enhance nephrotoxicity.
5. in combination with chloramphenicol may have mutual antagonism.
6. probenecid can prolong the excretion of Cefixime and elevated blood concentrations.
The above information is edited by the chemicalbook of Liu Yujie.
Precautions 1. Cross allergy: patients who are allergic to a cephalosporin or head neomycin (cephamycin) may be allergic to other cephalosporins or head neomycin. Who are allergic to penicillins, penicillin derivatives, or penicillamine may also be allergic to cephalosporins or head neomycin.
2. Contraindication: patients who are allergic to this product and other cephalosporins are disabled.
3. Used with caution:
(1) patients who are allergic to penicillin antibiotic are used with caution.
(2) pregnant women, lactating women, newborns and preterm children are used with caution.
(3) severe liver and kidney dysfunction are used with caution.
(4) highly allergic constitution are used with caution.
(5) the elderly, frail patients are used with caution.
4. Effects on the diagnosis:
(1) It may be false positive when copper sulfate method to determine urine sugar.
(2) direct antiglobulin test (Coomb's test) were positive reaction.
(3) a small number of patients after treatment may appear increased alkaline phosphatase, serum alanine aminotransferase and serum aspartate aminotransferase, serum creatinine and blood urea nitrogen.
5. Monitoring items when must use:
(1) long-term medication should regularly check liver and kidney function, and blood and urine routines.
(2) patients with liver and renal damage should monitor blood concentration when use Cefixime.
Chemical properties White or light yellow crystalline powder, odorless or slight smell. Soluble in ethanol or dimethyl sulfoxide, slightly soluble in acetone, almost insoluble in ethanol, hexane, ethyl acetate or water. Acute toxicity mindanao. Mouse, rat (mg/kg): All> 10,000 orally; 5000,7000 intravenous injection.
(Z)-Cefixime Disodium：C16H13N5O7S2Na2. Melting point＞250℃.
(E)-Cefixime trihydrate: C16H15N5O7S2 3H2O . A pale yellow solid, melting point is 218~225 ℃ (decomposition).
Uses The third-generation oral cephalosporin class of broad-spectrum antibiotics, has strong antibacterial effect on Gram-positive bacteria such as Streptococcus, and Gram-negative bacteria such as Neisseria gonorrhoeae, Haemophilus influenzae, , as well as E. coli , Klebsiella pneumoniae, Proteus mirabilis, which are resistance to cefaclor, cephalexin, cefadroxil resistant, and is stable for β-lactamase produced by various bacteria. Long-acting, efficient and can be administered once a day. Clinically used for respiratory tract infections,urinary tract infections and biliary tract infections caused by susceptible strains.

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