Manufacturer high quality Tilmicosin Cas 108050-54-0 with good price

Details:

Tilmicosin is a macrolide antibiotic primarily used in veterinary medicine to treat bacterial infections in livestock and poultry, particularly respiratory diseases. Below is a detailed overview of its properties and applications:

1. Basic Characteristics

Chemical Class: Macrolide antibiotic, structurally similar to tylosin.

• Mechanism of Action:

  • Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, blocking peptide chain elongation.

  • Effective against Gram-positive bacteria (e.g., Pasteurella, Mycoplasma) and some Gram-negative pathogens.

2. Primary Uses

• Animal Diseases:

  • Cattle and Swine: Treats respiratory infections (e.g., bovine pasteurellosis, swine mycoplasmal pneumonia).

  • Poultry: Manages chronic respiratory disease (CRD) in chickens.

  • Also used in sheep and goats for similar infections.

• Administration:

  • Injectable formulations (subcutaneous or intramuscular).

  • Oral suspensions or feed additives.

3. Advantages

Long-acting: Sustains therapeutic concentrations for days after a single dose.

Tissue Penetration: High concentrations in lungs and mammary tissues, ideal for respiratory and mastitis treatments.

Low Toxicity: Safe for target animals (e.g., cattle, swine) at recommended doses.

4. Safety Considerations

• Toxicity Risks:

  • Cardiotoxicity: Overdose may cause tachycardia or myocardial damage (notably in swine and certain canines).

  • Human Exposure: Not for human use; avoid direct contact (may cause allergies or irritation).

• Antimicrobial Resistance: Prudent use is critical to mitigate resistance development.

5. Comparison with Other Macrolides

6. Regulatory Guidelines

Contraindications: Prohibited in lactating animals (to prevent drug residues in milk).

Withdrawal Period: Mandatory pre-slaughter intervals (e.g., 14 days for cattle, 10 days for swine) to ensure food safety.

Global Standards: Complies with residue limits set by the FDA, EU, and other regulatory bodies.

7. Research Developments

Novel Formulations: Nanoemulsions and sustained-release formulations to enhance efficacy.

Combination Therapy: Synergistic effects with florfenicol or doxycycline for broader antimicrobial coverage.

Summary

Tilmicosin is a cornerstone in veterinary practice for managing respiratory infections, valued for its potency and prolonged action. Strict adherence to dosage and withdrawal protocols is essential to minimize resistance and ensure food safety. Human exposure must be avoided, emphasizing its veterinary-exclusive role. Ongoing research aims to optimize its delivery and therapeutic potential.