99 % Tazarotene Powder cas 118292-40-3 Anti-Acne Material

Details:

99 % Tazarotene Powder cas 118292-40-3 Anti-Acne Material 

 What is  Tazarotene   

Tazarotene is a retinoid prodrug which is converted to its active form, the cognate carboxylic acid of tazarotene, by rapid deesterification in animals and humans. Tazarotenic acid binds to all three members of the retinoic acid receptor (RAR) family: RARα, RARβ, and RARγ but shows relative selectivity for RARβ, and RARγ and may modify gene expression.  
 

 Tazarotene Applications: 
Tazarotene is most commonly used topically to treat acne, psoriasis (a skin disease in which red, scaly patches form on some areas of the body), and to reduce skin wrinkling and liver spots. Tazarotene is rated pregnancy category X, and should not be used by pregnant women. "There is limited evidence that tazarotene   benefit patients with moderate photodamage on the face: both are associated with skin irritation and erythema." In addition to tretinoin, which has been associated with greater skin improvements with high concentrations, tazarotene     creams are also found to be effective for photodamage, but at the expense of skin irritation. More evidence is needed before any recommendations can be made on oral or topical polysaccharides or hydroxy acids.  for acne vulgaris, several recent double blind studies have shown consistently superior efficacy for tazarotene and roughly equal tolerability for both treatments