cas 486460-32-6 ...

cas 486460-32-6 99% Sitagliptin powder

cas 486460-32-6 99% Sitagliptin powder

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  • Min.Order :1 Kilogram
  • Purity: 99
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Sitagliptin Sitagliptin powder 99% Sitagliptin

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  • Application:Artemisia annua is used as antimalarial drugs.
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cas  486460-32-6   99% Sitagliptin powder 

Product Name:    Sitagliptin
 CAS:    486460-32-6
MF:    C16H15F6N5O
MW:    407.31
EINECS:    690-730-1

 

Details:

 cas  486460-32-6   99% Sitagliptin powder  

Product Name:    Sitagliptin
 CAS:    486460-32-6
MF:    C16H15F6N5O
MW:    407.31
EINECS:    690-730-1 

Sitagliptin is an orally-bioavailable selective DPP4 inhibitor that was discovered through the optimization of a class of β-aminoacid-derived DPP4 inhibitors. It lowers DPP4 activity in a sustained manner following once daily administration, preserves the circulating levels of intact GIP and GLP1 following meals in both acute and chronic studies and reduces blood glucose levels without significant increases in hypoglycaemia. 

Sitagliptin phosphate (STG) is used to treat DM type 2 because it improves glycemic control by increasing the levels of active incretin hormones, GLP-1 (peptide-1) and GIP (glucose-dependent insulinotropic peptide). The activation of these incretins in β-pancreatic cells causes increased levels of cyclic adenosine monophosphate (cAMP) and intracellular calcium, with subsequent glucose-dependent insulin secretion (2). This hypoglycemic drug belongs to a new class called dipeptidyl peptidase IV inhibitors.  

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