cas 915087-33-1 99...

cas 915087-33-1  99 % purity Enzalutamide  powder

cas 915087-33-1 99 % purity Enzalutamide powder

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  • Min.Order :1 Kilogram
  • Purity: 99
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Enzalutamide Enzalutamide powder 99% Enzalutamide

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  • Appearance:white
  • Application:Artemisia annua is used as antimalarial drugs.
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cas 915087-33-1  99 % purity Enzalutamide  powder 

Product Name:    Enzalutamide
CAS:    915087-33-1
MF:    C21H16F4N4O2S
MW:    464.44
EINECS:    805-022-1

 

Details:

cas 915087-33-1  99 % purity Enzalutamide  powder 

Product Name:    Enzalutamide
CAS:    915087-33-1
MF:    C21H16F4N4O2S
MW:    464.44
EINECS:    805-022-1 

Enzalutamide (XTANDI) is an oral androgen receptor antagonist, which is approved by the current clinical research and the US FDA (Food and Drug Administration), for the development of post-chemotherapy metastatic castration tolerance of prostate cancer Treatment (i.e. patients with prostate cancer after chemotherapy, cancer or cancer cells are still growing in such patients), can extend the survival of patients. The incidence of prostate cancer in the United States is very high, with an annual increase of nearly 240,000 patients (the highest among all cancers), nearly 30,000 deaths every year (second only to lung cancer, breast cancer, colorectal cancer),but its incidence is low in China.

Enzalutamide is an androgen receptor inhibitor, the target of action is different from the approved cabbitaxel in 2010 and the approved abbitolone in 2011, and can competitively inhibit androgen and receptor binding, and can inhibition of androgen receptor nuclear transport and the interaction of the receptor and DNA. Vitro studies have shown that enzalutamide can inhibit prostate cancer cell proliferation and induce death, and enzalutamide reduces tumor volume in mouse prostate cancer xenograft model experiment. The main metabolite of enzalutamide is N-demethylol enamine, which shows similar inhibitory activity with enzalutamide in vitro.  

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