Estradiol 50-28-2 99%purity
β-Estradiol Basic information
Product Name: β-Estradiol
Synonyms: BETA-ESTRADIOL-16,16,17-D3;17BETA-ESTRADIOL-16,16,17-D3;β-Estradiol, 99% (dry wt.), ca 3% water;1,3,5-Estratriene-3,17beta-diol;17beta-Estradiol;3,17beta-Dihydroxy-1,3,5(10)-estratriene;Dihydrofolliculin;Estradiol
CAS: 50-28-2
MF: C18H24O2
MW: 272.39
EINECS: 200-023-8
Product Categories: powder or crystal;Inhibitors;Intermediates & Fine Chemicals;API;VIVELLE;Hormone Drugs;Analytical Chemistry;Biochemistry;Environmental Endocrine Disruptors;Estradiol, etc. (Environmental Endocrine Disruptors);Hydroxysteroids;Intracellular receptor;Pharmaceuticals;Steroid and Hormone;Steroids;Estrogen;Hormone
Mol File: 50-28-2.mol
β-Estradiol Chemical Properties
Melting point 178-179 °C(lit.)
alpha D25 +76 to +83° (dioxane)
Boiling point 355.44°C (rough estimate)
density 1.0708 (rough estimate)
refractive index 80.4 ° (C=1, Dioxane)
Fp 2℃
storage temp. room temp
solubility Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form powder
pka pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)
color White to off-white
Water Solubility Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Merck 14,3703
BRN 1914275
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey VOXZDWNPVJITMN-ZBRFXRBCSA-N
CAS DataBase Reference 50-28-2(CAS DataBase Reference)
NIST Chemistry Reference Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2)
EPA Substance Registry System Estradiol (50-28-2)
Safety Information
Hazard Codes T,Xn,F
Risk Statements 60-61-45-63-64-40-36-20/21/22-11-48
Safety Statements 53-22-36/37/39-45-36/37-26-16-36-20
RIDADR 2811
WGK Germany 3
RTECS KG2975000
F 8-10
HazardClass 6.1
PackingGroup III
HS Code 29372390
Hazardous Substances Data 50-28-2(Hazardous Substances Data)
Toxicity LD50 subcutaneous in rat: > 300mg/kg
β-Estradiol Usage And Synthesis
description β-Estradiol is an endogenous estrogenic hormone receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors. β-Estradiol is an activator of PI 3-kinase.
Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
Uses 17β-Estradiol is the major estrogen secreted by the premenopausal ovary.This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
β-Estradiol is used to study cell differentiation and transformations (tumorigenicity).
Indications and Usage Estradiol is a white or milky white ordorless crystalline powder. It is soluble in dioxane and acetone, slightly soluble in ethanol, and insoluble in water.
Estradiol is the intermediate between estradiol valerate and estradiol benzoate, and it is a type of estrogen drug. It can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Estradiol can promote and adjust the normal growth of female sex organs and secondary sex characteristics, promote mammary duct maturation and growth, and aid in posseting. Estradiol can also be used in biochemical research.
Adverse reactions In high dosages, estradiol can inhibit the release of anterior pituitary prolactin, thus decreasing breast milk secretion. However, nausea, vomiting and endometrial hyperplasia-induced bleeding may occur. Patients with liver or kidney failure should use with caution.
Contradictions Do not use on breasts, vaginal area and vaginal mucosa.
Chemical Properties White or almost white, crystalline powder or colourless crystals.
Chemical Properties Estradiol, 17-β-is an odorless white to yellow crystalline substance.
Uses 17β-Estradiol is the major estrogen secreted by the premenopausal ovary.This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
Uses Estradiol is the major estrogen secreted by the premenopausal ovary.
Uses Estradiol USP (Estrace) is used to treat Breast cancer; prostatic carcinoma.
Application β-Estradiol has been used:
for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)
as a supplement in in vitro maturation medium (IVM), which is used as a control medium
in estrogen-induction assay
Definition ChEBI: The 17beta-isomer of estradiol.
Acquired resistance Estradiol is the most potent endogenous estrogen, exhibiting high affinity for the ER and high potency when administered parenterally. When administered orally, estradiol is promptly conjugated in the intestine and oxidatively metabolized by the liver, resulting in its low oral bioavailability and therapeutic effectiveness.
General Description Estradiol, estra-1,3,5(10)-triene-3,17β-diol, is the most activeof the natural steroid estrogens. Although its 17β-OHgroup is vulnerable to bacterial and enzymatic oxidation toestrone, it can be temporarily protected as anester at C3 or C17, or permanently protected by adding a17α-alkyl group (e.g., 17α-ethinyl estradiol, the most commonlyused estrogen in oral contraceptives). The increasedoil solubility of the 17β-esters (relative to estradiol) permitsthe esters to remain in oil at the IM injection site for extendedperiods. These derivatives illustrate the principles of steroidmodification. Transdermal estradiolproducts avoid first-pass metabolism, allowing estradiol tobe as effective as oral estrogens for treating menopausalsymptoms. A new transdermal spray, Evamist, was approvedin 2007. Estradiol itself is typically not very effective orallybecause of rapid metabolism, but an oral formulation of micronizedestradiol that allows more rapid absorption of thedrug is available (Estrace). In addition to the oral and transdermalproducts, estradiol is also available in gel, cream, andvaginal ring formulations. The commercially available estradiolesters are the following:
Estradiol 3-acetate, USP (oral; vaginal ring)
Estradiol 17-valerate, USP (IM injection)
Estradiol 17-cypionate, USP (IM injection).
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