4-Androstenedione(4AD)

Details:

Androstenedione Chemical Properties
Melting point     170-171 °C(lit.)
Boiling point     368.77°C (rough estimate)
alpha     D30 +199° (in chloroform)
density     1.0655 (rough estimate)
refractive index     1.4709 (estimate)
Fp     2℃
storage temp.     Controlled Substance, -20°C Freezer
color     Dimorphous: Needles from acetone, or crystalsfrom hexane
Water Solubility     57.28mg/L(25 ºC)
Merck     13,643
InChIKey    AEMFNILZOJDQLW-QAGGRKNESA-N
CAS DataBase Reference    63-05-8(CAS DataBase Reference)
NIST Chemistry Reference    Androst-4-ene-3,17-dione(63-05-8)
EPA Substance Registry System    4-Androstenedione (63-05-8)
Safety Information
Hazard Codes     Xn,T,F
Risk Statements     40-64-52-22-61-60-36-20/21/22-11
Safety Statements     22-24/25-36-45-36/37-53-26-16
RIDADR     UN 1648 3 / PGII
WGK Germany     3
RTECS     BV8150000
HS Code     29372900
Hazardous Substances Data    63-05-8(Hazardous Substances Data)
MSDS Information
Provider    Language
Androstenedione    English
SigmaAldrich    English
Androstenedione Usage And Synthesis
Biological Metabolism    The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.
Description    Androstenedione (CRM) (Item No. ISO60161) is a certified reference material categorized as an anabolic androgenic steroid. Androstenedione is a precursor of testosterone (Item Nos. ISO60154 | ISO00154 | 15645) and estrone . Androstenedione is regulated as a Schedule III compound in the United States. Androstenedione (CRM) (Item No. ISO60161) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Chemical Properties    White to Off-White Solid
Uses    Testosterone precursor and metabolite with androgenic activity. Controlled substance (anabolic sterid)
Definition    ChEBI: A 3-oxo Delta4-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.
Safety Profile    An experimental teratogen. Otherexperimental reproductive effects. Questionablecarcinogen with experimental tumorigenic data. Whenheated to decomposition it emits acrid smoke andirritating fumes.
Purification Methods    Crystallise the dione from hexane. It is soluble in *C6H6, CHCl3 and EtOH. It has max at 239nm. It is a precursor of estrone or testosterone and has androgenic activity. [Ruzicka & Wettstein Helv Chim Acta 18 980 1935, Beilstein 7 III 3636, 7 IV 2381.]
Androstenedione Preparation Products And Raw materials
Raw materials    beta-Sitosterol-->3-keto-23,24-bisnorchol-4-en-22-ol-->CAMPESTEROL-->Cholesterol-->(8S,9R,10S,13S,14S,17S)-9,17-dihydroxy-10,13-dimethyl-2,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-one
Preparation Products    Spironolactone-->5B-ANDROSTANE-3,17-DIONE-->Androsta-1,4-diene-3,17-dione-->Testosterone undecanoate-->Androst-3-en-17-one,(5)-->5α-Androstane-3,6,17-trione-->11α-Hydroxyandrost-4-ene-317-dione-->Methyl 3-oxo-4-androstene-17beta-carboxylate-->6-METHYLENEANDROST-4-ENE-3,17-DIONE