cas 1115-70-4 99 ...

cas 1115-70-4 99 % Metformin hydrochloride powdwer

cas 1115-70-4 99 % Metformin hydrochloride powdwer

Min.Order / FOB Price:Get Latest Price

1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 99
  • Payment Terms : L/C,T/T,

Keywords

Artemisinin Artemisinin powder 99% Artemisinin

Quick Details

  • Appearance:white
  • Application: metformin have been used in the treatment of type 2 diabetes.
  • PackAge:drum
  • ProductionCapacity:1000|Kilogram|Day
  • Storage:room
  • Transportation:

Superiority:

cas  1115-70-4  99 % Metformin hydrochloride  powdwer 

Product Name:    Metformin hydrochloride
CAS:    1115-70-4
MF:    C4H12ClN5
MW:    165.62
EINECS:    214-230-6 

Metformin is a biguanide with diverse biological activities. Metformin   increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.

 

Details:

cas  1115-70-4  99 % Metformin hydrochloride  powdwer 

Product Name:    Metformin hydrochloride
CAS:    1115-70-4
MF:    C4H12ClN5
MW:    165.62
EINECS:    214-230-6 

Metformin is a biguanide with diverse biological activities. Metformin   increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.

View All
Visit Store

You Might Also Like

Related Searches

Contact Supplier

Confirm to collect the product to my collection?

OKCancel

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View