(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline CAS:118864-75-8

Details:

(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is white to off-white powder.

Density 1.1± 0.1g /cm3

Boiling point 338.4±11.0 °C at 760 mmHg

Melting point 80-82ºC

Molecular formula C15H15N

Molecular weight 209.286

Flash point 166.9±14.7 °C

Accurate mass 209.120453

PSA 12.03000

LogP is 2.70

Appearance properties white solid

Vapor pressure 0.0±0.7 mmHg at 25°C

Refractive index 1.589

Application:

(S) -1-phenyl-1,2,3, 4-tetrahydroisoquinoline can be used to prepare sofinaxine. SolifenacinSuccinate, CAS No. 242478-38-2, chemical name 1-azazobicyclic [2.2.2] octane-8-group -(1S) -1-phenyl-3, 4-dihydro-1h-isoquinoline-2-formate succinate, It is a selective muscarinic M3 receptor antagonist developed by Astellas in Japan. It was first marketed in Netherlands, Germany, UK and Denmark in 2004, and in China in 2009. So far, it has been marketed in more than 50 countries and regions around the world. It has become an important drug for the treatment of overactive bladder (OAB) in Europe, the United States and Japan, and has been recommended by several authorities and guidelines. Its preparation is as follows: (S) -1-phenyl-1,2,3, 4-tetrahydroisoquinoline (I) was synthesized by reaction condensation with triphosgene under the condition of organic base (weak base). (S) -1-phenyl-3, 4-dihydro-1h-isoquinoline-2-formyl chloride (II) was obtained. Compound II was heated directly under the catalysis of organic base by one-pot method without separation. It was condensed with (R) -3-quininocyclol to obtain Solinaxine (III), which was then salted with succinic acid to produce Solinaxine (IV) succinate.

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4.  How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.