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3-Hydroxyazetidine hydrochloride 3-Hydroxyazetidine Hydrochloride azetidin-3-ol hcl
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Azetidine 3-ol hydrochloride is an unbreakable ADC linker used in the synthesis of antibody drug conjugates (ADC). Azitin-3-ol hydrochloride is also an alkyl chain based PROTAC linker that can be used to synthesize PROTAC.
Related categories
Research Fields>>Cancer
Signal Pathways>>Antibody Drug Couplings>>ADC Connector
Signal Pathways>>Protein Lysis Targeted Chimera>>PROTAC Linker
Target point
Non clear
In vitro research shows that ADC is composed of antibodies, which connect to ADC cytotoxic cells through ADC linkers [1]. PROTAC contains two different ligands that are connected through ligands; One is the ligand of E3 ubiquitin ligase, and the other is the ligand of the target protein. PROTAC utilizes the intracellular ubiquitin proteasome system to selectively degrade target proteins
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