CasNo.204255-11-8,Oseltamivir phosphate,(204255-11-8) Suppliers

1 Kilogram	FOB Price:USD 50.0000 -100.0000

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Purity: 98%
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Keywords

Oseltamivir phosphate NTERMEDIATES OF OSELTAMIVIR Ro 64-0796/002

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Appearance:White powder
Application:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and activity against the cyclin B/CDK1 complex is 1000 times less t...
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ProductionCapacity:100|Metric Ton|Month
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Details:

Oseltamivir photosphate (GS 4104) is a neuraminidase inhibitor used for the prevention and treatment of influenza (influenza A and B).
Related categories
Signal Pathways>>Anti Infection>>Influenza Virus
Research Fields>>Infection
Target point
Influenza A and B [1]
In vitro study of oseltamivir phosphate (OP) is a prodrug that is easily absorbed from the gastrointestinal tract after oral administration, and is mainly converted into osemivir carboxylate (OC) through liver esterase [1]. Oseltamivir photosphate is a widely used anti influenza sialidase inhibitor. Using one-way ANOVA testicles, using 305 μ M osemivir phosphate treatment (p=0.005 and p<0.0001) significantly reduced the metabolic activity of CMA07 and CMT-U27 cell lines. Compared to the control cells, at 0.305 μ M (p=0.9781), 3.05 μ M (p=0.7436) and 30.5 μ No statistically significant changes were observed in the treatment of M (p=0.9623) with osemivir phosphate. Finally, in order to evaluate the effect of osemivir phosphate on programmed cell death in CMA07 and CMT-U27, and considering 305 μ M osemivir phosphate treatment impairs cellular metabolic activity and uses TUNEL assay for programmed cell death measurement. 24 hour oseltamivir phosphate treatment, especially 305 μ M. Significantly increased DNA fragmentation in CMA07 (p=0.001) and CMT-U27 (p=0.0002), indicating a promotion of programmed cell death compared to lower concentrations of osemivir or PBS [2].
Mice treated with oseltamivir phosphate in vivo showed significantly more inflammatory infiltration in primary tumors (p=0.01). Ki-67 antigen and caspase-3 protein were used to evaluate the proliferation and apoptosis of CMT-U27 xenograft tumor cells, respectively. In fact, there was no difference in the expression of Ki-67 and caspase-3 (p=0.2) between mice treated with osemivir and untreated mice [2].
For each condition, CMA07 and CMT-U27 cells were cultured in triplicate on a 24 well plate: 0.305 μ M. 3.05 μ M. 30.5 μ M and 305 μ M phosphate oseltamivir and PBS were used as controls. Cells were counted daily in the Neubauer room at a dilution of 0.4% trypan blue 1:2 for 7 days, and a volume conversion factor of 1mm 3 was used (1 × 104) Perform cell counting. This measurement is repeated 3 times and the growth curve is tracked [2].
Animal experimental mice [2] Female NIH (S) II nu/nu nude mice, 4-6 weeks old, using needle 25 in a breast fat pad × 106 live CMT-U27 dog