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Methylprednisolone aceponate Methylprednisoloni aceponas [Latin] Advantan
1. Product advantages
High purity, all above 98.5%, no impurities after dissolution
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Product Introduction:
Methylprednisolone acetate (ZK 91588) is a glucocorticoid and anti-inflammatory drug with weak systemic effects. Acetylprednisolone is a selective glucocorticoid receptor ligand. Acetylmethylprednisolone can be used for research on eczema and other inflammatory skin diseases [1] [2] [3].
Related categories
Research Fields>>Inflammation/Immunology
Signal Pathways>>G Protein Coupled Receptors/G Proteins>>Glucocorticoid Receptors
In vitro studies on the inhibition of collagenase promoter activity by methylprednisolone acetate (in Hela cells), IL-12p40 secretion induced by lipopolysaccharide (in human PBMC cells), and interferon induced by plant agglutinin- γ Secretion (in human PBMC company), integrated circuit 50 is 9.3, 16.8, and 15.2 nM, respectively [3]. Methylprednisolone acetate activated the millimeter TV promoter and Tate activity, which were 21.8 and 20.5 nM at week 50, respectively [3]
In vivo study of methylprednisolone acetate (topical application, 50 μ, The Ivan blue edema model caused by croton oil has anti-inflammatory effects, with an international 50 of 0.0015% and low systemic side effects [1]. Methylprednisolone acetate (0.0001% -0.1% local application) inhibits edema formation in irritating contact dermatitis in mice and rats, with a 50th edition of 0.002% [3]. Animal model: Stimulating contact dermatitis in mice and rats [3] Dose: 0.0001% -0.1% Administration: Local application, 10 µ L in mice and 20 µ L in rats. Result: Significant inhibition of ear canal inflammation.
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