CasNo.480-23-9,3',4',5,7-TETRAHYDROXYISOFLAVONE,(480-23-9) Suppliers

1 Kilogram	FOB Price:USD 50.0000 -100.0000

Min.Order :1 Kilogram
Purity: 98%
Payment Terms : T/T,Other

Keywords

3',4',5,7-TETRAHYDROXYISOFLAVONE 3-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one Santol

Quick Details

Appearance:White powder
Application:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and activity against the cyclin B/CDK1 complex is 1000 times less t...
PackAge:fiber can
ProductionCapacity:100|Metric Ton|Month
Storage:Seal and store in a cool and dry place
Transportation:By sea/air/land

Superiority:

1. Product advantages
High purity, all above 98.5%, no impurities after dissolution
We will test each batch to ensure quality
OEM and private brand services designed for free
Various cap colors available
We can also provide MT1 peptide powder
2. Factory advantages
Professional research team
More than 5 doctors in high-tech R&D laboratories
More than 1000 m2 of factory production line to ensure stable supply
More than 1200 factories to manufacture products and control quality
3. Service advantages
24-hour online service
Track package information and update it for customers
Professional sales team
Accept small order service
Redelivery service if detained by customs

Details:

Product Introduction:
Orobol is a major soybean isoflavone with various pharmacological activities, including anti skin aging and anti obesity effects. Orobol inhibits CK1 ε、 VEGFR2, MAP4K5, MNK1, Musk, TOPK, and TNIK (IC50=1.24-4.45 μ M) . Orobol also inhibits the PI3K subtype (PI3K α/β/γ/ K/ δ IC50=3.46-5.27 μ M) [1] [2].
Related categories
Signal pathway>>PI3K/Akt/mTOR signal pathway>>PI3K
Research Fields>>Metabolic Diseases
Signal Pathways>>Cell Cycle/DNA Damage>>Casein Kinase
Signal Pathways>>Stem Cells and Wnt Pathways>>Casein Kinases
In vitro study of Orobol competing with CK1 through ATP ε Binding and targeting casein kinase 1 ε Play an anti obesity role [2]. Orobol (5-20 μ M) Effectively inhibit the phosphorylation of 4E-BP1 induced by MDI (isobutylmethylxanthine, dexamethasone, and insulin (MDI)) [2].
In vivo research on Orobol can reduce weight gain and lipid accumulation induced by a high-fat diet without affecting food intake in C57BL/6J mice [2]. Animal model: C57BL/6J mice induced obesity by HFD [2] Dose: 10 mg/kg Administration: gavage; Daily 23 week results: Compared with the HFD group, there was a significant 17.3% decrease in body weight.

Hebei Sankai Chemical Technology Co., Ltd. is a new chemical enterprise integrating the research, manufacturing and supply of chemicals. Located in the beautiful "cattle city" Xingtai, Hebei Sankai Chemical Technology Co., Ltd. is mainly engaged in the research of chemical fertilizer. At the same time, we have made great breakthroughs in food, feed additives, cosmetics, dyes and industrial chemicals. Our company spirit of "integrity management, quality control, customer first" belief, at home and abroad enjoy high reputation.