Chemical raw material 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid / DOTA CAS 60239-18-1

Details:

Description of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid from Wuhan Fortuna Chemical Co.,Ltd

Basic Information of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid
Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid
CAS NO.	60239-18-1
Assay	98.56%
Appearance	White powder
Pacakge	1kg/Foil Bag,25kg/Drum/Box
MOQ	1kg
Storage	Cool and dry place
Shelf Life	2 Years
Brand	Fortunachem

Specifications(COA) of Chemical raw material 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid / DOTA CAS 60239-18-1

 

Items	Specifications	Results
Characteristics	Colorless or off-white powder	White powder
Melting Point (℃)	264- 268	265.1-266.7
Loss on drying	≤0.5%	0.15%
Residue on ignition	≤0.1%	0.07%
Assay	≥98%	98.56%
Conclusion	Compiles With the above standards.

 

Introduction of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, commonly abbreviated as DOTA, is a macrocyclic compound that is widely used in the field of chemistry and medicine, particularly in the development of contrast agents for magnetic resonance imaging (MRI) and in radiopharmaceuticals for diagnostic imaging and therapy.

 

Structure and Properties:

Chemical Formula: C16H28N4O8

Molecular Weight: 404.42 g/mol

Structure: DOTA consists of a 12-membered ring containing four nitrogen atoms (tetraaza) and four acetic acid groups attached to the nitrogen atoms. The macrocyclic ring provides a stable framework for binding metal ions.

 

Applications:

MRI Contrast Agents: DOTA is used to chelate (bind) gadolinium ions (Gd³?) to form gadolinium-DOTA complexes. These complexes are highly stable and are used as contrast agents in MRI to enhance the quality of the images by altering the magnetic properties of nearby water molecules.

 

Radiopharmaceuticals: DOTA can also chelate various radioactive metal ions, such as yttrium-90 (Y-90), lutetium-177 (Lu-177), and indium-111 (In-111). These radiolabeled DOTA complexes are used in targeted radiotherapy and diagnostic imaging. For example, DOTA-conjugated peptides can target specific receptors on cancer cells, allowing for precise delivery of the radioactive isotope to the tumor site.

 

Research and Development: DOTA and its derivatives are used in various research applications, including the development of new diagnostic and therapeutic agents, due to their ability to form stable complexes with a wide range of metal ions.

 

Advantages:

High Stability: The macrocyclic structure of DOTA provides exceptional stability to the metal complexes, reducing the risk of metal ion release in the body.

 

Versatility: DOTA can chelate a variety of metal ions, making it useful for multiple applications in medical imaging and therapy.

 

Biocompatibility: DOTA and its metal complexes are generally well-tolerated in biological systems, making them suitable for clinical use.

 

In summary, 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a versatile and highly stable chelating agent used extensively in medical imaging and radiopharmaceuticals. Its ability to form strong complexes with metal ions makes it invaluable in enhancing the efficacy and safety of diagnostic and therapeutic procedures.

FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q	Can I get a sample for free
A	For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q	How to confirm the product quality before placing orders
A	Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
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A	For small and low value order, we accept CreditCard, MaterCard,VISA, and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q	What is your shipment way
A	For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q	How long is your after-sales service
A	We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q	How do you treat quality complaint
A	We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is  the members of Hubei E-commerce Chamber.

 

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.

 

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.

 

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.

 

Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid with good quality and best price, welcome to contact us to get COA/TDS/MSDS of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid.