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Adapalene 1838-39-7 Adapalene Intermediates
1-(5-Bromo-2-Methoxyphenyl)-Adamantane CAS:104224-63-7
Name | 1-(5-Bromo-2-methoxy-phenyl)adamantane | |
Synonyms | 1-(5-Bromo-2-methoxyphenyl)-tricyclo[3.3.1.1(3,7)]decane; 2-(1-Adamantyl)-4-bromo-anisole | |
Molecular Structure | ||
Molecular Formula | C17H21BrO | |
Molecular Weight | 321.25 | |
CAS Registry Number | 104224-63-7 |
HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture.
With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exporting pharmaceuticals, veterinary drugs, feed additives, intermediates, fine chemicals, plants extracts, pesticides, food & nutrition additives.
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Adapalene Intermediates
1-(5-Bromo-2-Methoxyphenyl)-Adamantane CAS:104224-63-7
Ethyl 4-(Ethoxycarbonyl)piperidine-1-Acetate CAS:1838-39-7
Items Specifications Results
Appearance: yellow to white crystalline powder Complies
Identification: IR spectrum Complies
Loss on drying: 0.5%max. 0.1%
Water(KF): 0.5%max. 0.1%
Residue on ignition: 0.1%max. 0.02%
Specific rotation: +820~+890 +86.90
Residual solvents:
Methanol: 300ppm max. 25ppm
Ethanol: 500ppm max. Undetected
Acetone: 500ppm max. 4ppm
Dichloromethane: 600ppm max. 126ppm
Ethyl acetate: 500ppm max. Undetected
Related substance(HPLC):
Compound Ⅴ: 0.2%max. Undetected
Iso: 0.2%max. Undetected
Dipyrrolidine D: 0.5%max. 0.45%
Impurity A at RRt~0.21: 1.7%max. 1.06 %
Impurity B at RRt~0.55: 0.6%max. 0.23%
Impurity C at RRt~1.26: 0.5%max. Undetected
Any other unidentified: 0.2%max. Undetected
Total impurities: 2.5%max. 1.45%
Assay(titration): 99.0%min. 99.6%
(calculated on dried basis)
Morpholine: 0.2%max. Undetected
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