cas 698387-09-6 99%...

cas 698387-09-6 99% Neratinib powder

cas 698387-09-6 99% Neratinib powder

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 99
  • Payment Terms : L/C,T/T,

Keywords

Neratinib Neratinib powder 99% Neratinib

Quick Details

  • Appearance:white
  • Application: Anti cancer
  • PackAge:drum
  • ProductionCapacity:1000|Kilogram|Day
  • Storage:room
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cas 698387-09-6 99% Neratinib  powder

Product Name: Neratinib
CAS: 698387-09-6
MF: C30H29ClN6O3
MW: 557.04
EINECS: 811-237-1

 

Details:

What is Neratinib

The receptor tyrosine kinase HER2 (ErbB2) is a key component of epidermal growth factor receptor complexes that are known to have central roles in cell proliferation and cancer. Neratinib is an orally active, irreversible inhibitor of the HER2 kinase (IC50 = 59 nM). It also potently inhibits several mutants of HER2 and shows 10-fold or greater selectivity over a wide variety of other kinases. As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefitinib .


Neratinib Function

Neratinib has been evaluated in clinical trials against cancers characterized by HER2 overexpression or HER2 activating mutations. Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM, respectively. irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer. Antitumor agent

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