cas 1420477-60-6 ...

cas 1420477-60-6 Acalabrutinib powder

cas 1420477-60-6 Acalabrutinib powder

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 99
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Acalabrutinib Acalabrutinib powder 99% Acalabrutinib

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  • Appearance:white
  • Application:Artemisia annua is used as antimalarial drugs.
  • PackAge:drum
  • ProductionCapacity:1000|Kilogram|Day
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cas  1420477-60-6  Acalabrutinib powder 

Product Name: Acalabrutinib
CAS: 1420477-60-6
MF: C26H23N7O2
MW: 465.51
EINECS: 814-272-0

 

Details:

What is Acalabrutinib
Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.


Acalabrutinib function
Acalabrutinib, is an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL).

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