NADPH / Tetrasodium Salt

Details:

NADPH / Tetrasodium Salt

 

NADPH is the reduced form of the coenzyme NADP+; used in anabolic reactions such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.
NADPH, Tetrasodium Salt is a A ubiquitous coenzyme that acts as an electron donor in many reactions utilizing dehydrogenase and reductase enzymes. It is generated by reduction of the electron acceptor NADP+. The following biological pathways involve NADPH: formation of carbohydrate from CO2 during photosynthesis, maintenance of high levels of reduced glutathione in erythrocytes, reduction of thioredoxin.

 

Item	Specification
Appearance	Off-White to white powder
Solubility	Soluble in water
Sodium content	≤1%
pH(100mg/ml)	2.0-4.0
Water content	≤5%
Methanol (by GC)	≤1%
Ethanol (by GC)	≤2%
Pb	≤0.5ppm
As	≤0.5ppm
Hg	≤0.5ppm
Cd	≤0.5ppm
Total microbial count	≤750 CFU/g
Coliform	≤3MPN/g
Assay of β-NAD (enzym.) (calc. on dry basis)	≥97%
Purity (HPLC)	≥98%

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1.One of the biologically active forms of nicotinic acid.  Differs from NAD by an additional phosphate group at the 2’position of the adenosine moiety.  Serves as a coenzyme of hydrogenases and dehydroge nases.  Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions.

2.NADPH tetra sodium salt is used as an ubiquitous cofactor and biological reducing agent.  β-NADPH is a coenzyme found in all living cells and is involved in redox reactions carrying electrons from one reaction to another.  It is used as an electron donor, cofactor for many redox enzymes including nitric oxide synthetase.

3.β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions.  The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation.  The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation.  NADPH is generated in vivio by the pentose phosphate pathway (PPP).

 

Application    
NADPH is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various biological reactions.  In plants, NADPH is produced by ferredoxin-NADP+ reductase in the last step of the electron chain during photosynthesis.  In animals is it predominantly produced by the pentose phosphate pathway, but is also generated by key mitochondrial enzymes.  NADPH provides the reducing equivalents for biosynthetic reactions and the oxidation-reduction involved in protecting against the toxicity of reactive oxygen species. It is also used for the synthesis of lipids and cholesterol and during the process of fatty acid chain elongation.
 

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Binbo Biological Co., Ltd. is located in the convenient transportation and beautiful scenery of Jining high-technology industrial zone - Jinxiang economic Development Zone. There is a 105 National road links north and south when Zaocao and Dongfeng Roads connect east and west. Besides, provincial expressway and Ji-Xu expressway which connect Beijing,Shanghai,Fuzhou, and several cities across the JinXiang economic development zone. More importantly, there are only 20 km to Jining airport and close to Qufu high-speed railway station.These convenient geographical conditions bring the development opportunities for this economic development zone.

Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and raw materials. Company was established in 2001, currently our company has more than 28 thousand square meters covering area. Factory buildings and workshops were establishsd by modern production requirements.There are three steps of development project which planned to invest around 60 million RMB. Currently the first step were finished and spent 28 million RMB, which met the production and office requirements.

Binbo is engaged in R&D with perfect equipments and advanced detecting instruments. The factory is in strict accordance with GMP standard in the course of design and construction.

 

 

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