Hot Selling N-Acetylneuraminic acid/Sialic Acid

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N-acetylneuraminic acid is the most widely distributed sialic acid (N-acylneuraminic acid) in nature, mainly composed of glycoproteins, glycolipids or bacterial capsular substances in animal cell membranes or secretions. In glycoproteins or glycolipids, the ketone group at the 2-position forms a glycosidic bond so that it is located at the non-reducing end of the sugar side chain, and its negative charge or unique chemical structure makes it have various physiological specificities. The enzyme (neuraminidase) that hydrolyzes and removes terminal N-acetylneuraminic acid is widely distributed in nature from viruses to animals. The terminal acidity has been clarified by the change in physiological activity of this enzyme Chemicalbook. The role of sugar residues. For example, this sugar residue constitutes the binding site of the influenza virus on the erythrocyte membrane and plays a major role in the mutual recognition mechanism of plasma glycoproteins and liver cells or in the recognition mechanism of lymphocytes to the circulation pathway. Although the biosynthetic pathway is somewhat different in animals and bacteria, they all go through N-acetylmannosamine or its 6-phosphate, which is catalyzed by specific pyrophosphatase and reacts with CTP to generate CMP-N-acetylneuraminic acid Afterwards, sugar chains are incorporated by glycosylation

Sialic acid is a carbohydrate that widely exists in nature and is also a basic component of many glycoproteins, glycopeptides and glycolipids, and has a wide range of biological functions, such as the regulation of blood protein half-life, the neutralization of various toxins, and cell adhesion , immune antigen-antibody response and protection against cell lysis. Biochemical derivatives of sialic acid are also commonly used in the synthesis of drugs.